Obesity Clinical Trial
Official title:
Comparison of Two Weight Reducing Diets in Obese Men
Obesity has become a global epidemic, and treating and preventing obesity appears to be one
of the world's greatest challenges. The disorder is associated with a wide range of metabolic
and hormonal changes, including the development of insulin resistance, changes in adipose
tissue function, increased levels of blood lipids, cardiovascular disease and obesity induced
fatty liver. Obesity is characterized by inflammation in adipose tissue, altered fat storage
capacity and increased exchange of lipids between adipose tissue and blood, and increased
secretion of cytokines from adipose tissue. Cytokines are believed to play a central role in
the regulation of adipose tissue, the size of adipocytes and other metabolic conditions.
The hepatic synthesis of lipoproteins and interaction with adipose tissue is essential for
the body's energy storages. The central role of the liver in energy supply, fat storage and
normalization of blood values implies the importance of investigating the interaction between
adipose tissue and liver to increase knowledge about the morbidity of obesity. Central
obesity and insulin resistance are clear risk factors for the development of fatty liver, but
the importance of diet is unclear. The common perception is that fatty liver condition can be
improved by a reduction in dietary fat and cholesterols, but the relationship is unclear, and
contradictory findings occur in epidemiological studies. It is therefore necessary to better
understand the impact of the different macro-nutrients.
The purpose of this study is to determine whether two weight reducing diets with equal
calorie levels that contain high or low fat differentially affects the adipose tissue
function, distribution of body fat, as well as tissue, blood and urine levels of inflammatory
markers, lipids, vitamins, hormones and other substances that may be related to metabolically
health.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04101669 -
EndoBarrier System Pivotal Trial(Rev E v2)
|
N/A | |
| Recruiting |
NCT04243317 -
Feasibility of a Sleep Improvement Intervention for Weight Loss and Its Maintenance in Sleep Impaired Obese Adults
|
N/A | |
| Terminated |
NCT03772886 -
Reducing Cesarean Delivery Rate in Obese Patients Using the Peanut Ball
|
N/A | |
| Completed |
NCT03640442 -
Modified Ramped Position for Intubation of Obese Females.
|
N/A | |
| Completed |
NCT04506996 -
Monday-Focused Tailored Rapid Interactive Mobile Messaging for Weight Management 2
|
N/A | |
| Recruiting |
NCT06019832 -
Analysis of Stem and Non-Stem Tibial Component
|
N/A | |
| Active, not recruiting |
NCT05891834 -
Study of INV-202 in Patients With Obesity and Metabolic Syndrome
|
Phase 2 | |
| Active, not recruiting |
NCT05275959 -
Beijing (Peking)---Myopia and Obesity Comorbidity Intervention (BMOCI)
|
N/A | |
| Recruiting |
NCT04575194 -
Study of the Cardiometabolic Effects of Obesity Pharmacotherapy
|
Phase 4 | |
| Completed |
NCT04513769 -
Nutritious Eating With Soul at Rare Variety Cafe
|
N/A | |
| Withdrawn |
NCT03042897 -
Exercise and Diet Intervention in Promoting Weight Loss in Obese Patients With Stage I Endometrial Cancer
|
N/A | |
| Completed |
NCT03644524 -
Heat Therapy and Cardiometabolic Health in Obese Women
|
N/A | |
| Recruiting |
NCT05917873 -
Metabolic Effects of Four-week Lactate-ketone Ester Supplementation
|
N/A | |
| Active, not recruiting |
NCT04353258 -
Research Intervention to Support Healthy Eating and Exercise
|
N/A | |
| Completed |
NCT04507867 -
Effect of a NSS to Reduce Complications in Patients With Covid-19 and Comorbidities in Stage III
|
N/A | |
| Recruiting |
NCT03227575 -
Effects of Brisk Walking and Regular Intensity Exercise Interventions on Glycemic Control
|
N/A | |
| Completed |
NCT01870947 -
Assisted Exercise in Obese Endometrial Cancer Patients
|
N/A | |
| Recruiting |
NCT05972564 -
The Effect of SGLT2 Inhibition on Adipose Inflammation and Endothelial Function
|
Phase 1/Phase 2 | |
| Recruiting |
NCT06007404 -
Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents
|
||
| Recruiting |
NCT05371496 -
Cardiac and Metabolic Effects of Semaglutide in Heart Failure With Preserved Ejection Fraction
|
Phase 2 |