Obesity Clinical Trial
Official title:
Comparison of Two Weight Reducing Diets in Obese Men
Obesity has become a global epidemic, and treating and preventing obesity appears to be one
of the world's greatest challenges. The disorder is associated with a wide range of metabolic
and hormonal changes, including the development of insulin resistance, changes in adipose
tissue function, increased levels of blood lipids, cardiovascular disease and obesity induced
fatty liver. Obesity is characterized by inflammation in adipose tissue, altered fat storage
capacity and increased exchange of lipids between adipose tissue and blood, and increased
secretion of cytokines from adipose tissue. Cytokines are believed to play a central role in
the regulation of adipose tissue, the size of adipocytes and other metabolic conditions.
The hepatic synthesis of lipoproteins and interaction with adipose tissue is essential for
the body's energy storages. The central role of the liver in energy supply, fat storage and
normalization of blood values implies the importance of investigating the interaction between
adipose tissue and liver to increase knowledge about the morbidity of obesity. Central
obesity and insulin resistance are clear risk factors for the development of fatty liver, but
the importance of diet is unclear. The common perception is that fatty liver condition can be
improved by a reduction in dietary fat and cholesterols, but the relationship is unclear, and
contradictory findings occur in epidemiological studies. It is therefore necessary to better
understand the impact of the different macro-nutrients.
The purpose of this study is to determine whether two weight reducing diets with equal
calorie levels that contain high or low fat differentially affects the adipose tissue
function, distribution of body fat, as well as tissue, blood and urine levels of inflammatory
markers, lipids, vitamins, hormones and other substances that may be related to metabolically
health.
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