Obesity Clinical Trial
Official title:
The Influence of Apolipoprotein C3 Variants on Liver Steatosis and Serum Liver Enzyme Values in Obese Children
Verified date | November 2013 |
Source | Far Eastern Memorial Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | Taiwan: Department of Health |
Study type | Observational |
In the past decades, obesity in children is much more prevalent in the world. Given the
increasing prevalence of pediatric obesity worldwide, fatty liver incidence is on the rise.
Genetic variant in apolipoprotein C3 (APOC3) gene is associated with increased liver fat
content in adults.
The aim of this study is to find out whether APOC3 single nucleotide polymorphism (SNP)
influence fatty liver in obese children and adolescent.
Status | Completed |
Enrollment | 500 |
Est. completion date | December 2014 |
Est. primary completion date | December 2014 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 6 Years to 18 Years |
Eligibility |
Inclusion Criteria: - Age 6-18 years old - Obesity definition: BMI > 95% according to the age- and gender-specific standard suggested by National Health Institute in Taiwan - Willing to give written informed consent by parents Exclusion Criteria: - Alcohol consumption - Chronic liver diseases, including hepatitis B, hepatitis C, Wilson disease and autoimmune hepatitis - Major systemic diseases, including cardiopulmonary disease, renal failure, cancer, and psychotic disorder |
Observational Model: Cohort, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
Taiwan | Far Eastern Memorial Hospital | New Taipei City |
Lead Sponsor | Collaborator |
---|---|
Far Eastern Memorial Hospital |
Taiwan,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | genotype distribution of APOC3 rs2854117 and rs2854116 polymorphisms in subjects with and without liver steatosis | Oct 2013 ~ Dec 2014 | No | |
Secondary | genotype distribution of APOC3 rs2854117 and rs2854116 polymorphisms in subjects with and without insulin resistance | Oct 2013 ~ Dec 2014 | No |
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