Obesity Clinical Trial
Official title:
The Influence of Apolipoprotein C3 Variants on Liver Steatosis and Serum Liver Enzyme Values in Obese Children
In the past decades, obesity in children is much more prevalent in the world. Given the
increasing prevalence of pediatric obesity worldwide, fatty liver incidence is on the rise.
Genetic variant in apolipoprotein C3 (APOC3) gene is associated with increased liver fat
content in adults.
The aim of this study is to find out whether APOC3 single nucleotide polymorphism (SNP)
influence fatty liver in obese children and adolescent.
The primary aim of this study is to assess the associations between to investigate the
association of rs2854117 C > T and rs2854116 T > C SNPs of the APOC3 gene with liver
steatosis, as measured by liver ultrasound.
As a secondary aim, the investigators will examine the associations between APOC3 rs2854117
C > T and rs2854116 T > C SNPs and serum alanine aminotransferase (ALT) and aspartate
aminotransferase (AST) levels. In addition, the investigators will further analyze the
association with other biomarkers, such as body mass index, adiponectin and insulin
resistance.
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Observational Model: Cohort, Time Perspective: Prospective
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