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Role of Cysteinyl Leukotrienes in the Pathogenesis of Asthma in Obesity

Obesity Clinical Trial

Official title:
Role of Cysteinyl Leukotrienes in the Pathogenesis of Asthma in Obesity

Clinical Trial Summary

The purpose of this study is to examine whether there are higher levels of cysteinyl leukotrienes in obese subjects than in non-obese subjects. Cysteinyl leukotrienes are pro-inflammatory substances that cause asthma by narrowing the airways of the lung. The investigators want to see if subjects with increased fat stores and therefore increased leptin, which is a fat-related protein that regulates leukotrienes, have increased levels of leukotrienes in the blood, lung and urine. The investigators would also like to determine the relationship between cysteinyl leukotrienes and exhaled nitric oxide levels in asthmatics with and without obesity. Nitric oxide is anti-inflammatory and suppresses leukotriene synthesis.

Clinical Trial Description

This is a cross-sectional observational study to characterize the association between obese asthmatics and the inflammatory mediators cysteinyl leukotrienes. Our hypothesis is that altered adipokine levels in obesity result in augmented cysteinyl leukotriene synthesis that play a significant role in the pathogenesis of asthma in these subjects. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01158573
Study type Observational
Source University of Michigan
Contact
Status Completed
Phase N/A
Start date July 2010
Completion date May 2013
View Details
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