Obesity Clinical Trial
Official title:
What Ventilator Settings Are Most Comfortable for Patients With COPD or Obesity.
No studies have been done to examine whether patients with obstructive lung disease and obesity are more comfortable on some ventilator settings than on others. The purpose of the current study is to examine this question systematically.
Methods: Demographic and physiologic data will be recorded. Investigators will begin
measurements more than 60 minutes after last dose of sedative and measurements to occur when
no major interventions are planned or medications are scheduled. Then patients will undergo
the following ventilator settings (all of which are within ranges ordinarily employed) in
random order for 3 minutes of each setting (pressures measured midway i.e. 1.5 minutes - at
each interval to ensure safety; stopped if static airway pressure>30 cmH2O):
1. Assist control
1. Tidal volumes of 6 ml/kg, 8 ml/kg and 10 ml/kg
2. Flow regimes: constant (CF) and decelerating (dec) at 40, 60 and 80 L/min;
2. Pressure support (PS) 0, 10 and 20 cmH2O with PEEP=5 cmH2O
Patients will be randomized to receive the following in either forward or reverse order:
CF60L/min in 6 then 8 then 10 ml/kg; then at 8 ml/kg CF40, Dec40, Dec60, CF60, CF80, Dec80;
then PS=0, 10, 20 cmH2O.
In the last 30 second of each setting, patients will be asked to indicate their level of
comfort (1-10 in increasing comfort) using a visual analog Borg Score (when they can
see/write) or to indicate on their fingers when they cannot write.
;
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Supportive Care
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