Obesity Clinical Trial
Official title:
The Effect of Weight Loss Surgery on Preservation of Kidney Function and Cardiovascular Disease Risk Factors in Obese Patients With Stages 3-4 Chronic Kidney Disease: a Randomised Controlled Trial
Weight loss surgery is the most effective weight loss treatment available, but the direct
effect on chronic kidney disease is less widely understood. Early research shows some
improvement in kidney function may occur and candidacy for kidney transplantation can be
improved with weight loss following surgery. To date, no randomised controlled trial has
been performed to examine the effect of weight loss surgery on the progression of chronic
kidney disease.
This randomised trial will allocate patients to either lifestyle modification with diet,
exercise and pharmacotherapy, or weight loss surgery to remove two thirds of the stomach
using the laparoscopic sleeve gastrectomy procedure. This study aims to evaluate weight loss
surgery vs lifestyle modification in patients with chronic kidney disease with estimated
kidney function of 20-60% and morbid obesity (BMI 35-45) in terms of kidney function,
cardiovascular disease risk factors and all-cause mortality.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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