Obesity Clinical Trial
— CAPSPALOfficial title:
Effect of 4-week Dihydrocapsiate Ingestion on Resting Metabolic Rate: A Double-blind Randomized Parallel Arm Study
A 4 week intake of drug to find a natural substance that may modify energy balance and may enhance health in combination with lifestyle changes with possible decrease in body weight.
Status | Completed |
Enrollment | 79 |
Est. completion date | December 2014 |
Est. primary completion date | November 2009 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 20 Years to 60 Years |
Eligibility |
Inclusion Criteria: - Men between 20-60 years old - Healthy as assessed by medical history and standard medical exam - Weight-stable - Body mass index of 25 to 34.9 kg/m2 - Non-smoker - Sedentary lifestyle: not being physically active grater than 3 days/week for 20 min each time for the previous 6 months, and not participating in regular resistance exercise. Exclusion Criteria: - Subjects enrolled in a diet to increase or decrease body weight - Special diet or food aversiions to common foods - Has allergy to chilli pepper - Eating chilli peppers on a daily basis - Usually consuming more than 2 cups of tea or coffee/day - Usually consuming more than 4 cans of caffeinated soft drinks a day - Usually consuming more than 3 standard alcohol drinks/day - Regular use of medications (weight loss drugs, drugs affecting energy metabolism, drugs for depression) - Usual intake of illicit substances - Claustrophobia - Participating or having participated in another clinical trial during the last 4 weeks prior to the beginning of this study |
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Prevention
Country | Name | City | State |
---|---|---|---|
United States | Pennington Biomedical Research Center | Baton Rouge | Louisiana |
Lead Sponsor | Collaborator |
---|---|
Pennington Biomedical Research Center | Ajinomoto USA, INC. |
United States,
Galgani JE, Ryan DH, Ravussin E. Effect of capsinoids on energy metabolism in human subjects. Br J Nutr. 2010 Jan;103(1):38-42. doi: 10.1017/S0007114509991358. Epub 2009 Aug 12. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | The consumption of dihydrocapsiate will significantly increase resting energy expenditure and fat oxidation | 4 weeks | No |
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