Obesity Clinical Trial
Official title:
Meal Stimulating After Roux-en Y Gastric Bypass
In many studies, gastric bypass surgery led to total remission of type 2 diabetes (T2DM) as
early as 1 - 2 days after surgery before any real weight loss has occurred. This suggests
that the remission of the T2DM is due to the direct effect of the operation, more than the
secondary effect of the weight loss. The reasons for the major effect on the glucose
metabolism after gastric bypass surgery are still unaccounted for.
The aim of this project will be to unveil some of the mechanisms that explain the effect of
gastric bypass surgery on the glucose metabolism. Further more to find a better way of
testing patients that have just undergone gastric bypass surgery. It is not possible to test
patients who have just undergone gastric bypass surgery with normal oral glucose tolerance
test (OGTT) and a normal meal, because patients can only take in fluid and a normal OGTT
will often lead to dumping. Instead we will try to modify these tests - OGTT with lower
glucose level and meal-testing with a protein drink.
The hypothesis of the study is that the investigators can see changes in different hormones
and adipokines before and after surgery, even with modified OGTT and meal testing. The
project will consist of clinical trials on patients without T2DM that will undergo gastric
bypass surgery. The studies will take place before and within the first week after surgery.
The investigators will measure different hormones and adipokines after OGTT and a meal with
a protein drink. The investigators expect to see significant changes in some of the analyses
after the operation in patients undergoing gastric bypass.
n/a
Observational Model: Case-Only, Time Perspective: Prospective
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