Obesity Clinical Trial
Official title:
Effects of Obesity and Diet Induced Weight Loss on Cardiovascular Risk Factors, Vascular and Ventricular Structure and Function in Obese Men
Obesity is a growing epidemic and is associated with an increased risk of heart attack and
stroke. The investigators know that obesity leads to abnormalities in how the blood vessels
and the heart function and that these abnormalities are an important cause of this increased
risk in obese individuals. While improvements in these abnormalities have been reported with
marked weight reduction (eg surgery) and lifestyle changes including exercise training, it
is not clear that these abnormalities can be substantially reversed with standard dietary
interventions. Additional information is needed regarding the degree of weight loss
required, the time course of these improvements, nor the mechanisms. All of these have major
implications for the potential role of weight loss in the management of these patients.
The investigators will assess the effects of dietary induced weight loss in both the short
and long term on the function of blood vessels and the heart, and the relationship of any
changes with markers of inflammation that are present in obesity.
By understanding the factors that are important in reversing these abnormalities in obesity
the investigators will be better to identify and reduce heart attack and stroke in obese
individuals in the future.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
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