Obesity Clinical Trial
Official title:
Waist Circumference Versus Body Mass Index to Predict Severity of Gastroesophageal Reflux Disease
Gastroesophageal reflux disease (GERD) is a common and important disorder. Previous studies
have demonstrated the association of obesity with GERD, and now obesity is regarded as a
risk factor for GERD. Moreover, body mass index (BMI), an indicator of general obesity,
correlates with severity of symptoms and degree of erosive esophagitis. Waist circumference,
an indicator of abdominal obesity, has stronger correlation with intra-abdominal pressure
and low-grade inflammatory state when compared with BMI. Nevertheless the association of
waist circumference with severity of GERD has not been studied.
The primary aim of this study is to compare BMI with waist circumference for their
independent association with severity of GERD. The secondary aim is to evaluate independent
risk factors of severity of GERD.
This is a cross-section observational study. Outpatients presenting with acid reflux or
heart burn are interviewed with standardized questionnaire to quantify severity of symptoms.
The eligible patients undergo upper endoscopy to diagnose erosive esophagitis and further
classify the degree of erosions according to Los-Angels classification. Enrolled patients
receive anthropometric measurements to record body weight, body height and waist
circumference on the day of enrollment.
Two outcomes are studied: the severity of GERD symptoms and the Los-Angels Classification of
erosive esophagitis.
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Observational Model: Cohort, Time Perspective: Cross-Sectional
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