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Effect of Weight Loss on Myocardial Metabolism and Cardiac Relaxation in Obese Adults

Obesity Clinical Trial

Official title:
Effect of Weight Loss on Myocardial Oxygen Consumption and Left Ventricular Relaxation in Obese Adults

Clinical Trial Summary

Obesity adversely affects myocardial (muscular heart tissue) metabolism, efficiency, and diastolic function. The objective of this study was to determine if weight loss could improve obesity-related myocardial metabolism and efficiency and if these improvements were directly related to improved diastolic function.

Clinical Trial Description

This was a prospective, interventional study in obese adults ages 21 to 50 years of age to determine whether weight loss could improve obesity-related myocardial metabolism and efficiency. Two different mechanisms of weight loss were studied: diet and exercise and gastric bypass surgery. Positron emission tomography (PET) was used to quantitate myocardial oxygen consumption (MVO2) and myocardial fatty acid (FA) metabolism. Echocardiography with tissue Doppler imaging was used to quantify cardiac structure, systolic and diastolic function (left ventricular (LV) relaxation (E') and septal ratio (E/E')). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00572624
Study type Interventional
Source Washington University School of Medicine
Contact
Status Completed
Phase N/A
Start date June 2003
Completion date June 2014
View Details
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