Obesity Clinical Trial
Official title:
Prevalence and Metabolic Consequences of Relative Growth Hormone Deficiency in Abdominal Obesity
Obesity is one of the leading causes of cardiovascular-related diseases, including diabetes and heart disease. Obesity, and more specifically abdominal obesity, may cause decreased growth hormone (GH) levels. It is believed that GH deficiency may contribute to increased cardiovascular risk by affecting insulin resistance, inflammatory markers, and blood cholesterol levels. This study will determine the occurrence of GH deficiency in abdominal obesity and whether GH deficiency is associated with increased cardiovascular risk beyond traditional risk factors.
Obesity is associated with significant morbidity and mortality and is a primary public
health concern. Both the incidence and prevalence of obesity have increased over the last
several decades, with obesity now affecting an estimated 31% of the American population.
Recent data suggest that people with abdominal obesity commonly exhibit low levels of GH,
which affects the body's growth rate and the way the body uses food for energy. Low GH
levels and excess abdominal fat have been linked to improper functioning of the
cardiovascular system and, therefore, may increase one's risk of cardiovascular disease.
This study will determine the prevalence of GH deficiency in abdominal obesity and whether
GH deficiency is associated with increased cardiovascular risk beyond traditional risk
factors.
Participation in this observational study will last between 2 and 4 weeks. The study will
consist of two outpatient visits, held at either the Massachusetts General Hospital or
Massachusetts Institute of Technology. Visit 1 will last 4 hours and will include a physical
exam, medical history, blood draw, urine sampling, indirect calorimetry test, and growth
hormone releasing hormone (GHRH)+Arginine stimulation test. Eligible participants will
return within the next 3 weeks for Visit 2, which will last 5 hours. Before the second
visit, participants will be asked to record their food intake for 4 days on a food record.
During the visit, participants will have a repeat physical exam, urine sampling, and blood
draw. Participants will also undergo an oral glucose tolerance test, whole body DEXA scan,
abdominal computed tomography (CT) scan, and a carotid ultrasound. Participation in the
study will end after Visit 2.
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Observational Model: Case Control, Time Perspective: Cross-Sectional
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