Obesity Clinical Trial
Official title:
Obesity as a Risk Factor for Small for Gestational Age and Intrauterine Growth Restriction Infants
The purpose of this retrospective pilot study is to address the effect that obesity, in the
absence of other comorbidities, has on birth weight. We wish to determine if obesity is a
risk factor for small for gestational age (SGA) or intrauterine growth restricted (IUGR)
infants in our clinic population. There have been many studies linking maternal obesity with
fetal macrosomia, defined as fetal birth weight greater than 4500 grams. However, we have
noted that a percentage of our obese patient population has delivered either an SGA or IUGR
infant. SGA refers to a constitutionally small infant weighing less than the 10th percentile
for age. This refers to a genetically normal infant. IUGR refers to a fetus whose growth has
been restricted by influences other than normal genetics.
Our study population will consist of all women over the age 18 who delivered a term infant
either by vaginal delivery or cesarean section at Tulsa Regional Medical Center between July
1st 2004 and December 31st 2005.
The diagnosis of obesity will be based upon a Body Mass Index (weight in kilograms/height in
meters squared) of thirty or greater. We will look at the infant birth weight as recorded in
the patient's chart. We will define SGA or IUGR as birth weight less than the 10th
percentile for gestational age as defined previously. The control group will consist of
women meeting the same criteria except they will have a BMI less than thirty but greater
than 19.8 as low maternal weight is also a risk factor for IUGR. We will compare the average
birth weight and the rates of SGA/IUGR infants between the two groups and analyze using the
chi-squared method of analysis.
Status | Completed |
Enrollment | 420 |
Est. completion date | November 2006 |
Est. primary completion date | November 2006 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 18 Years to 50 Years |
Eligibility |
Inclusion Criteria: - Our study population will consist of all women over the age 18 who delivered a term infant either by vaginal delivery or cesarean section at Tulsa Regional Medical Center between July 1st 2004 and December 31st 2005. They must have had at least one visit at the Houston Park Ob-Gyn clinic, not including the initial prenatal lab visit, before delivery. Exclusion Criteria: - We will exclude women with multiple gestation, hypothyroidism, hyperthyroidism, heart disease, tobacco or drug use, gestational or preexisting diabetes, autoimmune disease of any form, hypertension, collagen vascular disease, any disease process resulting in decreased gastrointestinal nutrient absorption, or lung disease as these are conditions known to be risk factors for IUGR. |
Time Perspective: Retrospective
Country | Name | City | State |
---|---|---|---|
United States | Oklahoma State University Center for Health Sciences Houston Parke Clinic | Tulsa | Oklahoma |
Lead Sponsor | Collaborator |
---|---|
Oklahoma State University Center for Health Sciences |
United States,
Hulsey TC, Neal D, Bondo SC, Hulsey T, Newman R. Maternal prepregnant body mass index and weight gain related to low birth weight in South Carolina. South Med J. 2005 Apr;98(4):411-5. — View Citation
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