Effect of Bariatric Surgery on Cognition, Genetics and Lifestyle

Obesity, Morbid Clinical Trial

Official title:

Effect of Bariatric Surgery on Cognition, Genetics and Lifestyle

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT02085369
• Other study ID #: PH2014
• Secondary ID: PH2014
• Status: Recruiting
• Start date: January 2014
• Est. completion date: December 2023

Study information

• Verified date: March 2021
• Source: Uppsala University
• Contact: Magnus Sundbom, MD
• Email: magnus.sundbom[@]akademiska.se
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Obesity bariatric surgery patients usually lose more than 50% of their former obesity within a relatively short time (~ 2 years). There is still a lack of knowledge about underlying psychological and biological mechanisms of decline in body weight. The intention of this project is to investigate whether bariatric surgery is associated with patients' cognitive ability, lifestyle and/or gene expression and metabolomics.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 100
• Est. completion date: December 2023
• Est. primary completion date: December 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• First bariatric surgery

Exclusion Criteria:

• More than one surgery

Related Conditions & MeSH terms

• Obesity, Morbid

Locations

Country	Name	City	State
Sweden	Uppsala University Hospital	Uppsala

Sponsors (2)

Lead Sponsor	Collaborator
Uppsala University	Uppsala University Hospital

Country where clinical trial is conducted

Sweden, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Changes in gene expression profile (a.o. FTO, BDNF) following a standardized meal (before vs. after surgery)	Gene expression profiling (whole genome analysis, with first interest in FTO and BDNF expression) to assess changes in gene expression before vs. after surgery, and to associate gene expression with weight loss after surgery	1 year
Secondary	The effect of bariatric surgery on cognitive functioning (inhibitory control, selective attention)	No-Go go task (to assess inhibitory control) and Stroop tasks (to assess selective attention) will be measured to assess change in these cognitive functions before vs. after surgery, and to associate cognitive functioning with weight loss after surgery	Measures 1 y, 2 y, and 5 y after surgery.