Obesity, Morbid Clinical Trial
Official title:
How to Optimize Weight Loss Maintenance After a Very-low Calorie Diet?
Very-low calorie diets are relatively safe and effective in inducing significant weight loss,
when used in selective individuals and under clinical supervision. However, weight loss
maintenance in the long-term remains the main challenge, with many experiencing a significant
weight regain. Several compensatory mechanisms are activated under weight reduction, both at
the level of energy intake (such as increased appetite) and energy expenditure (such as
reduced energy expenditure), and increase the risk of relapse.
The main aim of this study is to compare the effect of two multidisciplinary lifestyle
interventions on weight loss maintenance at one year, after initial weight loss during 8
weeks very-low calorie diet. Participants will be allocated (non-randomly) to either an
outpatient program in the obesity unit of the local hospital, or to an inpatient program
consisting of a "continuous care" intervention, with three intermittent stays (each with
three-week duration) in a rehabilitation center over a one year period. Moreover, the
investigators aim to assess the impact of weight loss (achieved with a very low calorie diet)
and weight loss maintenance on compensatory mechanisms activated during weight reduction.
This study included a sub-study (n=30) to determine the timeline over which compensatory mechanisms (at both the level of energy expenditure and appetite control system) are activated with progressive weight loss. Additional measurements were taken at day-3, 5 and 10 % weight loss, and after 4 weeks weight stabilization (after gradually reintroduction of food). ;
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