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Obesity, Childhood clinical trials

View clinical trials related to Obesity, Childhood.

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NCT ID: NCT05424094 Not yet recruiting - Clinical trials for Overweight and Obesity

HRQoL in Overweight and Obese Children/Adolescents

Start date: July 1, 2022
Phase: N/A
Study type: Interventional

The primary aim of the present study is to record changes in the health-related quality of life (HRQoL) of children/adolescents participating in the multi-professional group programme 'kinderleicht' in 2022 over the course of the eleven-month active phase. In addition, these data will be examined for correlation with changes in BMI, waist and hip circumference, and motor performance. Secondarily, the study addresses the questions of whether the recording of HROoL by means of the KINDL questionnaire is practicable for the programme leaders and what benefit can be gained from the analysed data for future cohorts.

NCT ID: NCT05371821 Not yet recruiting - Obesity, Childhood Clinical Trials

Cardiac Assessment in Obese and Overweight Children

Start date: May 20, 2022
Phase:
Study type: Observational

Is to assess cardiac functions of overweight and obese children attending assiut University children hospital in one year duration .

NCT ID: NCT05302258 Not yet recruiting - Obesity, Childhood Clinical Trials

Attenuation Imaging in Hepatic Steatosis

Start date: April 14, 2022
Phase:
Study type: Observational

For obese and normal-weight children, the investigators assess the diagnostic performance of attenuation imaging (ATI) in the detection of hepatic steatosis in children.

NCT ID: NCT04329260 Not yet recruiting - Obesity, Childhood Clinical Trials

Mutation of the LEPR Gene at Reunion Island: Involvement in Pediatric Obesity

GREOL
Start date: March 2021
Phase:
Study type: Observational

The objective of this study is to estimate the proportion of the recurrent deletion Δ6-8 of the LEPR gene in the homozygous and heterozygous state in pediatric cases with severe and early ( before the age of 6) obesity (BMI ≥ IOTF-30) on Reunion Island.

NCT ID: NCT04100109 Not yet recruiting - Obesity, Childhood Clinical Trials

Evaluating the Metabolic Effects of Polylactose: A Novel Prebiotic

Start date: August 1, 2024
Phase: N/A
Study type: Interventional

This study will evaluate the feasibility and obtain a preliminary estimate of efficacy of feeding 15 g/day of a new novel prebiotic dietary fiber, termed polylactose, in 40 children (8-12 years old) with obesity (body mass index [BMI]-percentile >/= 95th) who have magnetic resonance imaging (MRI)-confirmed non-alcoholic fatty liver disease [NAFLD] (hepatic fat fraction >/= 5.5%), compared to a placebo of 15 g/d of cellulose, an inert dietary fiber.

NCT ID: NCT03994419 Not yet recruiting - Clinical trials for Overweight and Obesity

PErioperAtive CHildhood ObesitY

PEACHY
Start date: September 9, 2019
Phase:
Study type: Observational

The incidence of childhood obesity is at epidemic levels and increasing in the UK. Obese adults are considered a high-risk group of patients for general anaesthesia with published national guidelines on the best practice management. The proportion of children presenting for a procedure under general anaesthesia in the UK who are overweight or obese is currently unknown. Obese children are perceived to be at greater risk of complications from general anaesthesia. Previous non-UK studies suggest they take longer to recover from anaesthesia, require more medications to combat nausea and vomiting and are at greater risk of complications that may threaten their airway and breathing. This study involves reviewing the anaesthetic care record and patient notes to collect information relating to general anaesthesia and basic demographic data in children aged 2-16 years presenting for a procedure under general anaesthesia. The aims of this study are to establish the prevalence of obesity in the paediatric surgical population (i.e. the proportion of children attending UK hospitals for procedures under general anaesthesia who are overweight or obese) and to ascertain whether obese children are at increased risk compared to their healthy weight counterparts. This information will be used with the goal of reducing avoidable harm both at national and local level in the future.

NCT ID: NCT03516968 Not yet recruiting - Obesity, Childhood Clinical Trials

Monthly Boluses Versus Daily Doses for Correcting Blood Vitamin D Deficit in Obese Children and Adolescents

Obevidos
Start date: January 2023
Phase: Phase 3
Study type: Interventional

Childhood obesity prevalence is increasing and is a serious public health challenge. Indeed, according to INPES in 2006, overweight and obesity were affecting 18 % of French children between 3 and 17 years. 3 % of the boys and 4 % of the girls were classified as obese. Obese children are likely to develop chronic disease, starting at paediatric age, as cardiovascular or bone diseases, or type 2 diabetes. Vitamin D deficiency is recognized to play an essential role in bone metabolism and arterial hypertension and type 2 diabetes development. Obesity, in adults like in children, is associated with vitamin D deficiency. Common explanations for this low serum concentration of 25(OH)D in obese are the sequestration and/or the volumetric dilution of this lipid-soluble vitamin by adipose tissue. Therefore, obese population is at higher risk of developing cardiovascular and metabolic complications. The nutrition comity of French Pediatric Society (SFP) edit vitamin D supplementation recommendations (2012) for adolescents at risk of deficit: supplementation by trimestral loading dose of 80 000 to 100 000 UI of vitamin D. However, for obese patients, the deficit is difficult to cure with classical loading doses. It seems that these patients need higher dose of Vitamin D (two to three times higher). Likewise, the optimum scheme of administration (daily vs monthly) was never evaluated. Given new physiopathological data on pleiotropic role of vitamin D (on bone, cardiovascular system, adipose tissue) and in light of consequence of obesity on these systems, it seems essential to obtain data on vitamin deficit correction in obese children and adolescents and to evaluate bone status of these patients using modern imaging technics (high resolution peripheral quantitative computed tomography, HRpQCT). In this context, the OBEVIDOS study, randomised multi-centre prospective in 156 obese children and adolescent will allow us for : - evaluate vitamin D correction effect by two scheme of administration - establish an inventory of vitamin D status in this population - Modeling and simulation of vitamin D concentration in obese children and adolescents using a mathematical PBPK model - study, in a patient sub-group, the impact of vitamin D deficit and of obesity by itself on bone, by analysing bone micro-architecture

NCT ID: NCT03074929 Not yet recruiting - Obesity, Childhood Clinical Trials

Improving Childhood Obesity-Related Behavior Change Through Better Risk Communication

Start date: November 1, 2017
Phase: N/A
Study type: Interventional

One-third of American children are overweight or obese, leading to an increased risk for cardiovascular disease (CVD), early mortality, and other risks throughout their lifespan relative to normal weight children. In our pilot work, we found that 67-83% of parents underestimate a child's long-term risk of developing cardiovascular disease in adulthood and that parents thought their own child's risks were 13-15% lower than those of a typical child in their community, even controlling for family health and demographic characteristics. Parents were 40 times less likely to predict that their child, rather than a typical child in their community, would be overweight or obese in adulthood. These findings suggest that parents suffer from optimism bias, the tendency to overestimate one's chances of experiencing unlikely positive events. Belief that a child is at increased risk for adverse health outcomes in adulthood could be an important motivator for a family to initiate behavior changes and vice versa. The overall goal of this research is to develop provider-based risk communication approaches to motivate parents of obese children to engage in behavior change to protect their children from CVD and other obesity-related co-morbidities later in life. Specifically, the investigators will: 1. Develop risk communication methods that providers can use to better convey accurate information about a child's health behaviors, obesity status, and future health risks to parents. 2. Using an online experiment, we will evaluate the impact of new risk communication methods on parental engagement in behavior change. 3. Pilot test the feasibility, acceptability, and impact of new risk communication approaches in pediatric primary care clinics. This work will give pediatricians novel tools to effectively discuss the long-term consequences of childhood obesity with parents. The findings from this work will inform an interventional trial that will assess the impact of improved risk communication techniques on child behavior change and health outcomes.