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Obesity, Childhood clinical trials

View clinical trials related to Obesity, Childhood.

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NCT ID: NCT03356262 Active, not recruiting - Clinical trials for Diabetes Mellitus, Type 2

The QUebec Adipose and Lifestyle InvesTigation in Youth (QUALITY) Cohort

QUALITY
Start date: July 25, 2005
Phase: N/A
Study type: Observational

The QUebec Adipose and Lifestyle InvesTigation in Youth (QUALITY) Cohort study is a unique and comprehensive longitudinal study of 630 Caucasian children and their parents that was designed to investigate the natural history and determinants of childhood obesity and its cardiometabolic consequences.

NCT ID: NCT03330743 Recruiting - Obesity, Childhood Clinical Trials

Parent Mentor Interventions for Early Childhood Obesity

Start date: December 1, 2017
Phase: N/A
Study type: Interventional

The purpose of this clinical trial is to identify the most effective strategy for intervention to change behaviors and affect weight status in obese children 2-5 years of age within the context of early childhood education centers.

NCT ID: NCT03298334 Not yet recruiting - Obesity, Childhood Clinical Trials

Vaginal Microbiome Seeding and Health Outcomes in Cesarean-delivered Neonates.

Start date: November 1, 2017
Phase: N/A
Study type: Interventional

Neonates delivered by scheduled Cesarean Section will be randomized to receive vaginal seeding (exposing the infant to Mother's vaginal flora) or sham. Infants will be followed for three years to examine health outcomes including microbiome development, immune development, metabolic outcomes, and any adverse events.

NCT ID: NCT03283813 Not yet recruiting - Insulin Resistance Clinical Trials

ZIMBA: Clinical Trial in Paediatric Obesity

ZIMBA
Start date: October 1, 2017
Phase: Phase 4
Study type: Interventional

Myoinositol (MI) and D-chiro inositol (DCI) are isomeric forms of inositol that were found to have insulin-like properties, acting as second messengers in the insulin intracellular pathway; both of these molecules are involved in the increasing insulin sensitivity of different tissues to improve metabolic and ovulatory functions. Myoinositol is the predominant form that can be found in nature and food. Inositol has been mainly used as a supplement in treating several pathologies such as polycystic ovary syndrome (PCOS), metabolic syndrome, type 2 diabetes mellitus (T2DM) and gestational diabetes (GDM). In the case of GDM, a condition defined as a glucose impairment first detected in pregnancy, a preventive role of inositol for GDM onset was recognized. In addition, inositol has been studied as a therapeutic option for the treatment of GDM and T2DM. The main effect of inositol is decreasing the level of insulin resistance. Consequently, a potential role of inositol as a treatment option could be hypothesized for other conditions typically characterized by insulin resistance like metabolic syndrome and obesity. Zinc also plays an important role in insulin action and carbohydrate metabolism. It may also have a protective role in the prevention of atherogenesis. Several human studies have demonstrated that Zinc supplementation reduces total cholesterol, LDL cholesterol and triglycerides, in addition to increasing the HDL cholesterol levels. Studies have shown that diabetes is accompanied by hypozincemia and high levels of Zinc in urine. In addition Zinc is also an integral part of key anti-oxidant enzymes and Zinc deficiency impairs their synthesis, resulting in increased oxidative stress. A supplementation with Myo-Inositol and Zinc could represent a valid strategy in paediatric obesity in addiction to a standard approach. The purpose of our study is to evaluate the supplementation of Myo-inositol and Zinc in the treatment of paediatric obesity.

NCT ID: NCT03271801 Recruiting - Obesity, Childhood Clinical Trials

Skills Training Within a Family-based Obesity Treatment Intervention

Start date: June 1, 2016
Phase: N/A
Study type: Interventional

This study is investigating the impact of a skills training program in stimulus control of meals and snacks on zBMI. Participants will be randomized to a standard family-based obesity treatment intervention with education on child health or a standard family-based obesity treatment intervention with experiential learning about meal stimulus control strategies.

NCT ID: NCT03261466 Recruiting - Obesity, Childhood Clinical Trials

BIFI-OBESE: Clinical Trial in Paediatric Obesity

BIFI-OBESE
Start date: November 20, 2013
Phase: Phase 4
Study type: Interventional

Obesity is a major, public health concern that affects at least 400 million individuals and is associated with severe disorders including diabetes and cancers. Worldwide, the prevalence of overweight and obesity combined in children, adolescents and youth, between 1980 and 2013, increased to 47.1%, with alarming data also in developing countries. Obesity is often caused by imbalance between excessive caloric intake and reduced physical activity. Recently, microbial changes in the human gut was proposed to be another possible cause of obesity and it was found that the gut microbes from fecal samples contained 3.3 million non-redundant microbial genes. However, it is still poorly understood how the dynamics and composition of the intestinal microbiota are affected by diet or other lifestyle factors. Moreover it has been difficult to characterize the composition of the human gut microbiota due to large variations between individuals. The role of the digestive microbiota in the human body is still largely unknown, but the bacteria of the gut flora do contribute enzymes that are absent in humans for food digestion. Moreover, the link between obesity and the microbiota is likely to be more sophisticated than the simple phylum-level Bacteroidetes: Firmicutes ratio that was initially identified, and it is likely to involve a microbiota-diet interaction. Obese and lean subjects presented increased levels of different bacterial populations. It is hypothesized that the obese microbiome is set up to extract more calories from the daily intake when compared to the microbiome of lean counterparts. In addition, a caloric diet restriction impacted the composition of the gut microbiota in obese/overweight individuals and weight loss. In lean subjects there are Coriobacteriaceae, Lactobacillus, Enterococcus, Faecalibacterium prausnitzii, Prevotella, Clostridium Eubacterium, E. coli and Staphilococcus. By contrast, Bifidobacterium, Methanobrevibacter, Xylanibacter, Bacteroides characterize the composition of lean gut microbiota. For this reason, in a cohort of obese paediatric subjects with visceral adiposity, the aim of the study is to assess the efficacy of a supplementation with probiotic bifidobacteria with respect to a conventional treatment on weight loss and improvement of cardio-metabolic risk factors.

NCT ID: NCT03245775 Recruiting - Obesity, Childhood Clinical Trials

A Trial of Two Family-based Childhood Obesity Treatment Programs

Start date: June 1, 2017
Phase: N/A
Study type: Interventional

The primary aim is to determine the relative effectiveness in child BMI z-scores at 3, 6, and 12-months post baseline of iChoose+ versus Family Connections. Secondary aims are to determine (1) ongoing reach, fidelity, and implementation costs, (2) community capacity for implementation and sustainability, (3) relative impact on family eating/physical activity and parental weight, and (4) relative adherence and potential dose response relationships.

NCT ID: NCT03235440 Completed - Quality of Life Clinical Trials

Feasibility of the Camp Power Up Program on Children's Body Weight and Quality of Life

CampPowerUp
Start date: June 19, 2017
Phase: N/A
Study type: Observational

This study will evaluate the effects of a one week weight management summer camp on children's weight, quality of life, mood and feelings, self-esteem, weight management efficacy, enjoyment of physical activity, and body image.

NCT ID: NCT03205293 Enrolling by invitation - Physical Activity Clinical Trials

School-Based Intervention Program to Promote Healthy Eating and Physical Activity

Start date: March 1, 2011
Phase: N/A
Study type: Interventional

The purpose of this research is to develop, apply, and evaluate a school-based intervention program in East Jerusalem schools, designed to increase knowledge and to improve the attitudes and healthy behavior of schoolchildren, their teachers and their mothers' with regard to healthy eating and physical activity habits. The study tested the hypothesis that the impact of the entire school intervention program on students' lifestyles is mediated by their teachers' engagement in health promotion and by their mothers' involvement in school activity.

NCT ID: NCT03192566 Recruiting - Obesity, Childhood Clinical Trials

Acetaminophen Dosing in Obese Adolescents

Start date: August 2016
Phase: Phase 3
Study type: Interventional

Although there are numerous studies investigating the pharmacokinetic properties of intravenous acetaminophen in infants and children with normal weight, there are none in the obese pediatric patient . This study will investigate the pharmacokinetics and pharmacodynamics of acetaminophen (total Cl and Vd) in obese children and adolescents