Obese Clinical Trial
Official title:
Comparative Study Between the Effect of Volume-Controlled Ventilation and Pressure-Controlled Ventilation Volume Guaranteed in Obese Patients in Laparoscopic Assisted Surgery
The aim of this study is to compare the efficacy of the pressure controlled ventilation volume-guaranteed (PCV-VG) versus volume-controlled ventilation (VCV) modes as regards lung compliance and oxygenation index in obese patients undergoing laparoscopic assisted surgery especially in Trendelenburg position.
Status | Recruiting |
Enrollment | 64 |
Est. completion date | July 1, 2024 |
Est. primary completion date | July 1, 2024 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 16 Years to 60 Years |
Eligibility | Inclusion Criteria: 1. Age: 16 - 60 years old. 2. Sex: both males and females. 3. Undergoing elective Laparoscopic Surgery. 4. Obese patient with Body Mass Index between =30 Kg/m2. 5. American society of Anesthesiologist (ASA) class I/ II. Exclusion Criteria: 1. Patient refusal. 2. American society of Anesthesiology (ASA) III or IV. 3. Intraoperative hemodynamic instability. 4. Patients with pulmonary hypertension. 5. Obese patients on home O2 therapy 6. Pneumoperitoneum with CO2 with intra-abdominal pressure exceeding 15mmHg. 7. Anti-Trendelenburg position. 8. Asthmatic Patients. 9. Patients with advanced liver disease. 10. Patients with advanced renal disease. 11. Patients with advanced malignancy. 12. Pregnant females. |
Country | Name | City | State |
---|---|---|---|
Egypt | Ain Shams University | Cairo |
Lead Sponsor | Collaborator |
---|---|
Ain Shams University |
Egypt,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Oxygenation index | Oxygenation index =mean airway pressure × fraction of inspired oxygen (FiO2) × 100÷ Partial pressure of oxygen (PaO2) | Till the end of surgery | |
Secondary | Mean arterial blood pressure | Mean arterial blood pressure (MAP) will be monitored 10 minutes before anesthesia induction , immediately before onset of pneumoperitoneum, every 10 minutes in the first hour, and at the end of surgery. | Till the end of surgery | |
Secondary | Heart rate | Heart rate (HR) will be monitored 10 minutes before anesthesia induction , immediately before onset of pneumoperitoneum, every 10 minutes in the first hour, and at the end of surgery. | Till the end of surgery | |
Secondary | Oxygen saturation SpO2 | Oxygen saturation SpO2 will be monitored 10 minutes before anesthesia induction , immediately before onset of pneumoperitoneum, every 10 minutes in the first hour, and at the end of surgery. | Till the end of surgery | |
Secondary | Arterial PCo2 | Arterial blood gases will be analyzed using a blood gas analyzer before anesthesia induction and every 10 minutes in the first hour for arterial oxygen tension (paO2) , arterial CO2 tension (paCO2). | Till the end of surgery | |
Secondary | Lung compliance | Lung mechanics readings included peak air way pressure (Ppeak), plateau pressure (Pplat), mean airway pressure (Pmean), dynamic and static compliance of the respiratory system will be recorded after intubation and every 10 minutes in the first hour | Till the end of surgery |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT04105075 -
COPD in Obese Patients
|
||
Completed |
NCT04099654 -
The Effect of Core Stabilization Exercise Program in Obese Subjects Awaiting Bariatric Surgery
|
N/A | |
Recruiting |
NCT05857150 -
Exercise Response in Humans With Obesity
|
||
Completed |
NCT03532672 -
Early Effect of Fasting on Metabolic, Inflammatory, and Behavioral Responses in Females With and Without Obesity
|
N/A | |
Completed |
NCT02086448 -
Sleep Disordered Breathing, Obesity and Pregnancy Study (SOAP)
|
N/A | |
Completed |
NCT02618486 -
The Effects of Obesity on Non Surgical Periodontal Therapy
|
N/A | |
Completed |
NCT01724502 -
Mitochondrial Dysfunction in Diabetes
|
N/A | |
Completed |
NCT01724515 -
PGC-1 and Mitochondrial Dysfunction in Diabetes
|
N/A | |
Active, not recruiting |
NCT01634204 -
Efficacy of a Web-based Weight Loss Program
|
Phase 2 | |
Completed |
NCT01479933 -
Glucose Metabolism Effects of Vitamin D Supplementation in Prediabetes
|
N/A | |
Completed |
NCT01421589 -
Growth Hormone Treatment on Phosphocreatine Recovery in Obesity
|
N/A | |
Completed |
NCT01467817 -
Obesity/Overweight in Persons With Early and Chronic Spinal Cord Injury (SCI)
|
N/A | |
Completed |
NCT03528304 -
Native Women's Wellness: Contingency Management for Tobacco Cessation and Weight Loss
|
N/A | |
Completed |
NCT01726647 -
Metabolism Associated With Abdominal Fat Mass Distribution
|
N/A | |
Active, not recruiting |
NCT02125149 -
The Expecting Study
|
N/A | |
Completed |
NCT05737927 -
Pharmacodynamics and Pharmacokinetics of Different Glucose Bead Formulations in Obese Healthy Subjects
|
Phase 1 | |
Completed |
NCT05433506 -
Safety and Pharmacokinetics of HU6
|
Phase 1 | |
Completed |
NCT02871882 -
Ox Bile- Conjugated Bile Acids Sodium in Type II Diabetes Mellitus
|
Phase 2 | |
Completed |
NCT03298464 -
Study of NGM313 in Obese Participants
|
Phase 1 | |
Completed |
NCT05061173 -
Comparison of Aerobic, Resistance, and Combined Training in Overweight/Obese Hypertensive Adults
|
N/A |