Diabetes Clinical Trial
Official title:
PGC-1 and Mitochondrial Dysfunction in Diabetes, Aims 4 & 5
The purpose of this study is to determine whether insulin resistance is accompanied by "exercise resistance". Investigators will use mass spectrometry and proteomics analysis to test the hypothesis is that a bout of exercise that increases mitochondrial protein abundance in lean, healthy individuals is less effective in insulin resistant patients.
The investigators' prior research has focused on defining the changes in expression of
nuclear encoded mitochondrial genes that predict changes in insulin sensitivity in skeletal
muscle, with the goal of defining the molecular mechanisms underlying the connection between
mitochondrial dysfunction and insulin resistance in skeletal muscle.
Three groups of subjects will be studied: lean, healthy control subjects (n=12) obese
non-diabetic subjects (n=12) and patients with type 2 Diabetes Mellitus (n=12) for a total
of 36 subjects. Twenty subjects have completed the study at Arizona State University; the
remaining 16 subjects will be accrued at the Mayo Clinic in Arizona.
Subjects will come to the Mayo Clinic 4 times. On Study Day 1 Subjects will be screened with
a medical history & physical and a 75 g oral glucose tolerance test to determine if they are
eligible for the study. On Study Day 2, subjects will report to the clinic after an
overnight fast, undergo a euglycemic clamp (using deuterated glucose) to determine insulin
sensitivity, and in addition have a muscle biopsy (basal biopsy for comparison). On Study
Day 3, subjects will report to the clinic after an overnight fast, and undergo a Volume
Oxygen Maximum (VO_2 max) determination. On Study Day 4, subjects will report to the clinic
after an overnight fast to perform an exercise bout with muscle biopsy 30 minutes after the
end of exercise. This will be followed by an overnight fast, and an additional muscle biopsy
at 24 hours post exercise.
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Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science
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