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Role of Semaglutide in Restoring Ovulation in Youth and Adults With Polycystic Ovary Syndrome — RESTORE  

Obese Clinical Trial

Official title:
Role of Semaglutide in Restoring Ovulation in Youth and Adults With Polycystic Ovary Syndrome

Clinical Trial Summary

Girls and women 12-35 years old with obesity and polycystic ovarian syndrome who are on or off metformin, will receive a glucagon like peptide-1 receptor agonist intervention for 10 months to induce metabolic changes, weight loss and improve reproductive abnormalities.

Clinical Trial Description

Polycystic ovary syndrome is one of the most common endocrinopathies in women, presents with anovulation in adolescence, and reproductive dysfunction is related to excess weight. After a 4-month observation period of either no medication or metformin treatment, females aged 12-35 years with obesity and polycystic ovary syndrome will receive 10 months of a glucagon-like peptide-1 receptor agonist to induce metabolic changes, weight loss and improve reproductive abnormalities. We will assess the relationship between weight loss and reproductive function, as well as identify if age, hormonal and metabolic measures and such insulin sensitivity and insulin secretion predict the response to glucagon-like peptide-1 receptor agonist therapy. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05819853
Study type Interventional
Source University of Colorado, Denver
Contact Yesenia Garcia-Reyes, MS
Phone 720-777-6984
Email PCOSresearch@cuanschutz.edu
Status Recruiting
Phase Phase 3
Start date November 3, 2023
Completion date June 30, 2028
View Details
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