Nutritional Deficiency Clinical Trial
Official title:
Absorption of Zinc (Zn) From Zn-biofortified and Zn-fortified Maize in Young Zambian Children Between 24-36 Months
The objective of this study is to compare the quantity of Zn absorbed from an accurately weighed quantity (~100 g) of minimally milled control maize (~15 µg Zn/g maize), from biofortified maize (~30 µg Zn/g) and from the same control maize that has been fortified (total level of ~60 µg Zn/g) when fed to young children age 24-36 months whose major habitual food staple is maize.
Participating children were randomized to receive an accurately weighed quantity of
~100g/day of either the control, fortified or biofortified study maize for 1 day.
On day 1, mothers brought their child to the health center before breakfast. All meals were
extrinsically labeled with a zinc stable isotope (70Zn). Meals on this day were consumed in
the presence of the research staff. The quantities of nshima or porridge prepared and eaten
were accurately weighed and duplicate meals were collected for subsequent mineral analyses.
Between lunch and dinner on day 1 at the Health Center, a blood sample was collected for Hb
and plasma Zn analyses and, immediately after and through the same needle, a stable isotope
of zinc was intravenously administered into a forearm vein over 1-2 minutes. The family then
returned home.
Morning spot urine samples were collected twice daily starting on day 5 and continuing
through day 8. Once these collections were finished, the study for this child was complete.
Dietary Zn was measured from laboratory assays of the duplicate test meals. Fractional
absorption of Zn (FAZ) was measured by dual isotope tracer ratio methods in urine. Absorbed
Zn was calculated by multiplying dietary Zn by FAZ.
;
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05603585 -
Optimal Protein Supplementation and Early Exercise In Mechanically Ventilated Patients
|
N/A | |
Recruiting |
NCT05417672 -
Assessment of Relationship Between Preoperative Nutritional Status and Perioperative/Postoperative Conditions in Patients With Lung Cancer Scheduled for Lobectomy
|
||
Completed |
NCT04091165 -
Mobile APP Utilization for Enhanced Post-Operative Nutritional Recovery
|
||
Recruiting |
NCT05655910 -
Enhanced Nutritional Optimization in LVAD Trial
|
N/A | |
Completed |
NCT04117581 -
A Study to Investigate the Effect of Vitamin D3 Supplementation on Asthma Symptoms in Adults With Asthma (VITDAS)
|
N/A | |
Recruiting |
NCT06078488 -
Individualized Nutritional Care Bundle for Home Nursing Patients With Pressure Injuries.
|
N/A | |
Withdrawn |
NCT05073562 -
Nutrition Intervention to Address Anemia Among Adolescent Girls in Liberia
|
N/A | |
Recruiting |
NCT01342861 -
INAPEN Protocol for Impact of Breakfast Improvement
|
N/A | |
Completed |
NCT05244785 -
Health and Nutrition Survey on Shenzhen Children
|
||
Recruiting |
NCT06103526 -
Immunonutrition in ERAS Protocols in Gynecologic Oncology
|
N/A | |
Completed |
NCT05473546 -
Diarrhea and Stipsis in Critically Ill Patients (NUTRITI)
|
||
Completed |
NCT04829851 -
The PROTEIN Project
|
||
Completed |
NCT03202576 -
Nasogastric Tube Securement Comparison Study
|
N/A | |
Completed |
NCT04351828 -
Intestinal Permeability, Nutritional Status and Quality of Life in Celiac Disease
|
||
Completed |
NCT04866927 -
Bioavailability of Proteins From Plant Based Diets
|
||
Completed |
NCT04771377 -
Effect of Protein Supplementation and a Structured Exercise Program on Muscle in Women After Bariatric Surgery.
|
N/A | |
Completed |
NCT04401930 -
Eating Habits and Lifestyle Profile of an Italian Aging Cohort
|
||
Terminated |
NCT04629534 -
Mothers' Own Milk Optimization for Preterm Infants Project (MoMO PIP) Pilot Study
|
Phase 4 | |
Completed |
NCT03133364 -
Developing and Testing Delicious and Nutritious for the Old People
|
N/A | |
Recruiting |
NCT06035315 -
The 1000 First Day of Life : Effect of Multi Micronutrients Supplementation on Pregnancy Outcomes
|
N/A |