Quality of Life Clinical Trial
Official title:
The Investigation of Nutritional Status, Intestinal Permeability and Quality of Life in People With Celiac Disease
Celiac disease is defined as an autoimmune enteropathy with malabsorption of gluten protein.
In recent studies, it has been stated that in individuals diagnosed with celiac disease,
intestinal epithelial barrier integrity is impaired. Increased zonulin concentration in blood
is considered as an indicator of increased intestinal permeability.
Gluten-free diet is the only treatment of celiac disease. Adherence to gluten free diet
provides decreasing of intestinal permeability however gluten free diet has different aspects
on nutritional status and health related quality of life in people with celiac disease.
The aim of this study is to determine nutritional status, intestinal permeability and quality
of life in people with celiac disease. In the study,it primarily hypothesized that celiac
patients noncompliant to gluten-free diet may have increased circulating levels of zonulin
and increased intestinal permeability compared to celiac patients compliant to gluten-free
diet.
Celiac disease is defined as an autoimmune enteropathy that progresses with malabsorption of
gluten protein found in wheat, barley, rye and small intestinal mucosal inflammation in
individuals with genetic predisposition. Disruption of intestinal barrier integrity play role
in the pathogenesis of celiac disease. Zonulin levels increase in the disruption of
intestinal permeability in celiac patients.
At the present, the only treatment of celiac disease is life-long gluten-free diet and it
requires strict gluten elimination . With compliance to gluten-free diet, thickening of
intestinal mucosal layer, decreasing of villi atrophy and decreasing of transcellular
infiltration are observed. In other studies, it was stated that adherence to gluten-free diet
can repair intestinal permeability and decrease zonulin levels.
While compliance to gluten-free diet is a key point to prevent progression of the disease,
nutritional quality of the gluten-free diet affects nutritional status of patients.
Moreover,restricted diets in terms of energy or various nutrients affect health-related
quality of life. In studies examining all aspects of celiac disease, it has been stated that
health-related factors reduce the quality of life in celiac patients.
In conclusion, this study aims to investigate the presence of intestinal permeability with
serum zonulin levels in celiac patients, to evaluate nutritional status of patients with
anthropometric measurements and food consumption records, and to determine quality of life of
patients with validated celiac disease questionnaire. This study in Turkey, is also first
study that investigate all these three factors.
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