Primary Open Angle Glaucoma Clinical Trial
Official title:
A Single Center, Prospective, Open Label Study Assessing the Relationship Between the 24-hour Intraocular Pressure Pattern as Determined by Sensimed Triggerfish® and the 24-hour Blood Pressure Pattern in Patients With Primary Open Angle Glaucoma
Interplay between the increasing IOP and decreasing blood pressure (BP) during the 24-hour
period, especially in the nocturnal period, may lead to insufficient perfusion pressure of
the optic nerve and contribute to the glaucomatous damage in adjunct to the antero-posterior
vectorial mechanical impact on the lamina cribrosa, the translaminar pressure. Patients with
progressive VF loss showed greater nocturnal BP dips than patients with stable VF. Reduced
mean intraocular perfusion pressure (IOPP) was significantly associated with the extent of
glaucomatous damage. How the nycthemeral IOP fluctuation influences glaucoma progression has
not been studied in a prospective manner and remains to be elucidated.
The purpose of this study is to assess the relationship between the 24-hour IOP fluctuation
pattern and the 24-hour BP pattern in patients with primary open angle glaucoma (POAG). IOP
fluctuations will be monitored with SENSIMED Triggerfish®, a portable investigational device
using a contact lens sensor that monitors the IOP fluctuation continuously over 24-hours.
n/a
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label
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