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Low Tension Glaucoma clinical trials

View clinical trials related to Low Tension Glaucoma.

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NCT ID: NCT06266351 Not yet recruiting - Glaucoma Clinical Trials

EVALUATION OF CATS TONOMETER PRISM IN LASIK SUBJECTS

Start date: February 12, 2024
Phase:
Study type: Observational

The CATS Tonometer prism clinical study is intended to determine repeatability of intraocular pressure measurement in human corneas which have undergone a LASIK procedure when compared to a standard Goldmann prism, validating the human LASIK eye findings comparing CATS Tonometer and Goldmann prisms to intracameral pressure in cadaver eyes.

NCT ID: NCT06054763 Not yet recruiting - Glaucoma Clinical Trials

Buyang Huanwu Decoction and Normal Tension Glaucoma

Start date: October 1, 2023
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to test Buyang Huanwu Decoction in normal intra-ocular pressure glaucoma. The main question to answer is: the effect of Buyang Huanwu Decoction and its safety in patients with normal intra-ocular pressure glaucoma. Participants will take 3 grams of Buyang Huanwu Decoction or placebo for 12 weeks. Researchers will compare treatment group and placebo group to see if the visual acuity, visual field would be improved.

NCT ID: NCT06030193 Not yet recruiting - Glaucoma Clinical Trials

Qlaris Phase 2 Study in NTG Patients

Start date: June 10, 2024
Phase: Phase 2
Study type: Interventional

Qlaris' Phase 2 clinical trial investigating the safety, tolerability, and ocular hypotensive efficacy of QLS-111 in normal tension glaucoma patients.

NCT ID: NCT06023927 Not yet recruiting - Clinical trials for Obstructive Sleep Apnea

Obstructive Sleep Apnea as a Risk Factor for Normal Tension Glaucoma and a Crucial Step in Preventing Blindness

Start date: April 15, 2024
Phase:
Study type: Observational

The purpose of this research study is to learn more about the relationship between Obstructive Sleep Apnea (OSA) and Normal Tension Glaucoma (NTG). OSA is a nighttime disorder of the upper airway that causes an intermittent lack of oxygen while sleeping. NTG is a type of glaucoma that occurs despite the normal intraocular pressure levels, making its detection more difficult. Left untreated, irreversible optic nerve damage and extensive vision loss can result. Previous research has shown some evidence between OSA and the development of NTG. The investigators are researching whether undergoing treatment for OSA would help to improve the vascular health to the retina, and in effect, improve the early signs of visual dysfunction seen with diagnostic testing.

NCT ID: NCT05371977 Recruiting - Clinical trials for Normal Tension Glaucoma

Deep Sclerectomy Versus Trabeculectomy in Normal Tension Glaucoma

DSTRENTG
Start date: May 31, 2022
Phase: N/A
Study type: Interventional

The purpose of this study is to assess whether deep sclerectomy is as effective in lowering intraocular pressure (IOP) as trabeculectomy in patients with normal tension glaucoma.

NCT ID: NCT05279716 Recruiting - Ocular Hypertension Clinical Trials

Study in Prostaglandin Associated Peri-orbitopathy Switching From Prostaglandin Monotherapy to Omidenepag Isopropyl

NOPAPS
Start date: February 15, 2022
Phase: Phase 4
Study type: Interventional

This study is for patients have been using prostaglandin analogue eye drops with a preservative for 3 months or more and have been diagnosed with prostaglandin-associated peri-orbital disease. the investigators would like to confirm the real world evidence(RWE) of safety and efficacy after changing to Eybelis ophthalmic solution 0.002%.

NCT ID: NCT05075369 Not yet recruiting - Clinical trials for Normal Tension Glaucoma

Water Drinking Test Study and Disc Hemorrhages in Normal Tension Glaucoma

Start date: October 2021
Phase: N/A
Study type: Interventional

Disc hemorrhages are a known risk factor for progression of glaucoma. A positive water drinking test is also associated with progression of primary open glaucoma. The purpose of this study is to determine if patients with normal tension glaucoma and disc hemorrhages have a positive water drinking test. Patients with normal tension glaucoma and a disc hemorrhage will be recruited to undergo a water drinking test prior to any change in their treatment.

NCT ID: NCT04981886 Not yet recruiting - Clinical trials for Normal Tension Glaucoma

Intraocular Pressure Reduction Efficacy of Rhopressa and Lumigan in Normal Tension Glaucoma

NTG
Start date: August 2021
Phase: Phase 4
Study type: Interventional

Glaucoma is the second leading cause of blindness and the first leading cause of irreversible vision loss worldwide. The intraocular pressure (IOP) is the only modifiable risk factor for all the spectrum of glaucoma. Reducing IOP in glaucoma increases the likelihood of preventing progression of the disease and preserving the quality of life of the patient. Although prostaglandin analogs (PGAs) and prostamides (PMs) are de facto first-line treatment options for managing glaucoma, it is a common clinical experience to see their treatment effects plateau to a level beyond which no clinically significant IOP reduction is likely. It is also common to find minimal IOP treatment effects in the following conditions: patients with normal tension glaucoma (NTG), patients with thicker central corneal thickness (CCT), and patients with higher levels of corneal hysteresis (CH). CH is a possible proxy for the ability of the scleral tissue around the optic nerve to dissipate energy away from the optic nerve fibers. Netarsudil, a rho-kinase inhibitor was recently approved by the FDA for the treatment of glaucoma and ocular hypertension. There is a paucity of research on the efficacy of netarsudil in patients with NTG, thicker CCT, and higher levels of CH. This study aims to investigate the above issues by evaluating the efficacy of netarsudil and bimatoprost in subjects with NTG, thicker corneas, and higher levels of CH. Hypotheses - Netarsudil will have non-inferior efficacy compared to Bimatoprost in treating NTG. - Corneal thickness and corneal hysteresis will reduce the efficacy of netarsudil similar to bimatoprost in NTG. - Netarsudil will change corneal thickness and corneal hysteresis similar to bimatoprost in NTG.

NCT ID: NCT04857827 Completed - Clinical trials for Normal Tension Glaucoma (NTG)

A Study to Evaluate Safety and Tolerability of QLS-101 in NTG

Start date: September 15, 2021
Phase: Phase 2
Study type: Interventional

A randomized active-controlled multi-site double-masked 28 day study to evaluate the safety and tolerability of QLS-101 versus timolol maleate Preservative Free (PF) 0.5% ophthalmic solution in subjects with normal tension glaucoma

NCT ID: NCT04651530 Recruiting - Cataract Clinical Trials

Endoscopic Cyclophotocoagulation in Normal Tension Glaucoma

ECPNTG
Start date: December 8, 2020
Phase: N/A
Study type: Interventional

The purpose of this study is to assess whether endoscopic cyclophotocoagulation added to cataract surgery lowers intraocular pressure more than cataract surgery alone in patients with normal tension glaucoma.