Primary Open Angle Glaucoma Clinical Trial
Official title:
Clinical Cohort Study of Association Between Steady State Phenytoin Treatment and Better Clinical Parameters of Glaucoma
since glaucoma is considered an optic neuropathy, new treatments for glaucoma are being
continuously investigated, including neuroprotection.
Previous studies implied that phenytoin, a potent anti-convulsive drug, has a
neuroprotective role, and Na+ channels blockage was suggested as a possible mechanism.
This study predicts that glaucoma patients taking Phenytoin will have a less advanced
glaucoma as compared to patients not taking the drug. Glaucoma severity will be determined
by visual acuity, visual fields, optic disc cupping and nerve fiber layer thickness
The study will examine adult patients who suffer from glaucoma and epileptic disorders on
the same time. the study group will include glaucoma patients, being treated with oral
Phenytoin for their epileptic disorder. The study group will be compared to 2 control
groups:
- Glaucoma patients with epileptic disorder,receiving different medication than Phenytoin
- Glaucoma patients with no epileptic disorder.
4 parameters will be evaluated for all groups:
1. Best corrected visual acuity
2. Optic disc cupping
3. visual fields and general perimetric indices
4. peripapillary retinal nerve fiber layer.
Every participant in the study,after giving his informed consent, will be evaluated by a
senior ophthalmologist in a single office appointment. The appointment will include a visual
acuity, complete ophthalmic examination,Humphrey perimetric visual field testing and
peripapillary RNFL thickness measurement by OCT.
no drug or other treatment will be given to the participants
after data collection, average +/-Standard deviation for the 4 parameters will be compared
between the 3 groups. Student T-test and one- way ANOVA will be used for statistical
analysis.
;
Observational Model: Cohort, Time Perspective: Cross-Sectional
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