Clinical Trials Logo

Clinical Trial Summary

Nonsuicidal self-injury (NSSI) is defined as the direct, deliberate destruction of one's own body tissue without suicidal intent, typically including behaviors such as cutting, burning, or hitting oneself. The risk of engaging in NSSI is particularly high during adolescence. NSSI is associated with impairments in emotion regulation and NSSI behavior serves as an attempt to regulate emotion. We propose to examine whether training adolescents with NSSI to self-regulate using emotion regulation skills to down-regulate hemodynamic activity of the salience network, involved in emotional processing. Moreover, we propose to examine whether limbic-prefrontal cortex connectivity can be increased following neurofeedback, thereby helping adolescents find an optimal way to emotionally regulate with the help of neurofeedback, instead of engaging in NSSI to regulate emotions. We also aim to examine effects of real-time biofeedback by investigating if adolescents can regulate their psychophysiological activity during emotional reactivity with biofeedback. Sixty participants with NSSI will be recruited and offered either real-time functional magnetic resonance imaging (rt-fMRI-NF) (n = 30) or real-time biofeedback (n = 30) training. Participants each each condition will then be randomized to either an active or a control condition (n = 15/group). Participants will take part in three runs of feedback training. Changes in emotional reactivity as measured with facial electromyography (EMG) before and after feedback training will be the proximal outcome measure together with changes of the blood oxygenation level dependent (BOLD) response during real-time fMRI-neurofeedback for the neurofeedback training. Proximal outcome measures for the biofeedback will include psychophysiological measures of emotional reactivity (facialEMG). More distal outcome measures for both neuro- and biofeedback will be measures of NSSI: frequency, methods and severity as well as self-report measures of difficulties with regulating emotions, emotional reactivity and psychiatric symptoms.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05656001
Study type Interventional
Source Region Östergötland
Contact Maria Zetterqvist, PhD
Phone +46 10-1034339
Email maria.zetterqvist@regionostergotland.se
Status Recruiting
Phase N/A
Start date September 10, 2021
Completion date March 2024

See also
  Status Clinical Trial Phase
Completed NCT05702086 - Making SPARX Fly in Nunavut: Pilot Testing an E-intervention for Boosting Resilience Against Youth Depression N/A
Completed NCT05684614 - Interoception and Emotion Regulation
Completed NCT05376397 - Testing THRIVE 365 for Black Sexual Minority Men (On The Daily) N/A
Completed NCT04110548 - Emotion and Craving Regulation Among Individuals With Internet Gaming Disorders N/A
Not yet recruiting NCT05558527 - The Social Regulation of Threat-related Vigilance and Arousal N/A
Recruiting NCT03039387 - Effects of tDCS on Cognitive Control and Emotion Regulation in Depressed Patients N/A
Recruiting NCT06024083 - Skills Video Intervention for Chinese/Chinese Americans N/A
Recruiting NCT05867316 - Supplementing Brief Psychotherapy With a Mobile App N/A
Recruiting NCT05949047 - Smartphone-based Cognitive Emotion Regulation Training for Unpaid Primary Caregivers of Persons With Alzheimer's Disease N/A
Recruiting NCT06033053 - Real-time Neurofeedback Training of Fronto-limbic Regions Functional Connectivity N/A
Recruiting NCT05390034 - Improving Emotion Regulation Flexibility: Testing the Efficacy of an Emotion Regulation Program in College Students N/A
Recruiting NCT06432959 - Incorporating Positive Affect Promoting Activities Into Cognitive Behavioral Therapies N/A
Recruiting NCT05131425 - Facing Your Fears: Adolescents With ASD and Intellectual Disability N/A
Recruiting NCT06049407 - Intervention on Socio-emotional Development and Well-being Through ICTs in Early Adulthood N/A
Completed NCT04999514 - Examining the Effects of Parenting Interventions on Children With Attention-Deficit / Hyperactivity Disorder (AD/HD) and Their Parents N/A
Completed NCT05149066 - #KindGirlsInACTion: A Programme for the Promotion of Mental Health of Female Adolescents N/A
Active, not recruiting NCT05264415 - Intergenerational Transmission of Traumatic Stress N/A
Recruiting NCT06458920 - Social Facilitation of Emotion Regulation in Adolescence N/A
Completed NCT03698591 - Testing a Neurocognitive Model of Distancing Using Transcranial Magnetic Stimulation. N/A
Active, not recruiting NCT05542498 - Promoting Stress Management and Engagement in Introductory Physics Courses With Mindfulness and Relaxation N/A