Non-ST Elevation Myocardial Infarction Clinical Trial
Official title:
Effect of Tailored Use of Tirofiban in Patients With Non-ST-elevation Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention
Investigators aimed to test the beneficial effect of tirofiban, a GPIIb/IIIa antagonist, for Non-ST-Elevation Acute Coronary Syndrome Patients who has high resistance to clopidogrel.
Some patients have a poor response to dual antiplatelet therapy (DAPT), and it can result in
a poor prognosis after percutaneous coronary intervention (PCI). Devices like Ultegra Rapid
Platelet Function Analyzer (VerifyNow®) enable us to quantify platelet reactivity quickly in
the catheter laboratory. This means that the poor responders to DAPT can be identified, and
the patients' outcomes can be improved by providing additional antiplatelet agents.
Tirofiban, a GP IIb/IIIa inhibitor, is a potent antiplatelet agent which is recommended for
Non-ST-Elevation acute coronary syndrome (NSTE-ACS) with high risk at presentation. However,
its role is not clear for patients stabilized with standard medical treatment but with a poor
responsiveness to DAPT.
In this study, Investigators administered tirofiban on top of DAPT to patients with NSTE-ACS
undergoing PCI who have a high platelet reactivity (HPR) identified by VerifyNow.
To the best of our knowledge, there are few studies conducted with tirofiban for tailored
antiplatelet therapy. Moreover, this is the first randomized study with NSTE-ACS patients for
tailored use of tirofiban under the guidance of platelet reactivity.
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