Neuropathic Pain Clinical Trial
Official title:
The Effect of Central Sensitization and Neuropathic Pain on Patients Reported Outcomes Following Total Knee Arthroplasty
Verified date | October 2022 |
Source | The Catholic University of Korea |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
It has been well known that central sensitization (CS) is a risk factor for inferior outcomes following total knee arthroplasty (TKA). However, there are still insufficient studies on the relationship between CS and neuropathic pain (NP), and the effects of CS and NP on the patient-reported outcome measures (PROMs) of patients who underwent TKA. The purpose of this study was to investigate the relationship between CS and NP and whether CS and NP were associated with PROM in patients undergoing TKA.
Status | Completed |
Enrollment | 312 |
Est. completion date | December 31, 2021 |
Est. primary completion date | December 31, 2021 |
Accepts healthy volunteers | |
Gender | All |
Age group | 60 Years and older |
Eligibility | Inclusion Criteria: - Primary knee degenerative osteoarthritis - Patients for total knee arthroplasty over the age of 60 - Patients with 2 year postoperative medical records Exclusion Criteria: - Rheumatoid arthritis - Other inflammatory arthritis - Neuropsychiatric patients - Hepatic insufficiency - Renal insufficiency - Allergy or intolerance to study medications - Patients with an acetylsalicylic acid of IV (angina, congestive heart failure, dementia, cerebrovascular accident) - Chronic opioid use (taking opioids for longer than 3 months) - Alcohol, drug abuser - Narcotics addiction |
Country | Name | City | State |
---|---|---|---|
Korea, Republic of | The Catholic Univerisity of Korea Seoul St Mary's hospital | Seoul |
Lead Sponsor | Collaborator |
---|---|
The Catholic University of Korea |
Korea, Republic of,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score | Western Ontario and McMaster University Arthritis Index (WOMAC) scale is a validated questionnarie for evaluation of patients who underwent knee operation. The questionnaire consists of 24 tiems, with five pain-related categories (score range 0-20), two stiffness categories (score range 0-8), and 17 physical functional categories (score range 0-68). All items were scored on a 5-point Likert scale (0 = none, 1 = slightly, 2 = moderate, 3 = serious, 4 = extreme). Total score range is 0-96. The lower the score, the better the result. | 2 years after TKA |
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