Tariquidar-ondansetron Combination in Neuropathic Pain

Status Completed

Clinical Trial Summary

Prospective, randomized, double-blind, placebo controlled, cross-over proof of concept study. To determine the pharmacokinetics and tolerability of co-administration of 5-HT3R antagonist ondansetron with a P-glycoprotein inhibitor tariquidar, in patients with neuropathic pain.

Clinical Trial Description

The investigators hypothesize that co-administration of a 5-HT3 receptor antagonist ondansetron (single 16mg dose) with p-glycoprotein inhibitor tariquidar (single 4mg/kg dose) vs placebo in a cross-over prospective randomized study, will: 1. Be tolerable in patients with neuropathic pain. 2. Increase the cerebrospinal fluid (CSF) to plasma ratio of ondansetron after intravenous administration, compare to ondansetron alone 3. Result in a greater reduction in pain intensity than with ondansetron alone. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04603066
Study type	Interventional
Source	Washington University School of Medicine
Contact
Status	Completed
Phase	Phase 1/Phase 2
Start date	January 31, 2021
Completion date	November 3, 2023

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