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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT04538170
Other study ID # 611/2013BO2
Secondary ID
Status Completed
Phase
First received
Last updated
Start date September 1, 2014
Est. completion date July 1, 2019

Study information

Verified date August 2014
Source University Hospital Tuebingen
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Phantom pain is associated with cortical reorganization after amputation. This phenomenon should not play a role in transsexual women, since the cortical representation of the male sex organs is presumably altered. The study investigates the incidence of phantom pain in this patient population. For this study the following question should be investigated: Is the incidence of phantom pain and local chronic postsurgical pain lower in sex reassignment surgery from male to female compared to inguinal tumor orchidectomy?


Description:

Phantom pain is a common and much studied phenomenon after amputation.The loss of visceral organs is also associated with phantom pain. Under entirely different conditions than the removal of a tumorous testicle, sex reassignment surgery from male to female sex occurs in transsexual women. In this operation, parts of the penis and both testicles are removed and a plastic surgical transformation is made into a female genital.The surgical trauma is greater compared to an orchidectomy. The sex reassignment surgery is expressly desired, the amputated tissues are rejected or perceived as not belonging to the patient's own body and thus do not appear as a loss. The group of patients with tumor orchidectomy acts as a control group. In addition to the incidence of phantom pain and chronic local postoperative pain in comparison between the two groups, the secondary objectives of the study were defined as the occurrence of phantom pain, the type of pain and the intensity of pain. Two patient groups were compared, the group after sex reassignment surgery (GAC) and the group after inguinal orchidectomy for testicular tumor (ORC). A total of 265 transgender women were written to, 46 of whom had undergone surgery in Tübingen and 219 in Munich. The operations took place between 2002 and 2014. For the group of patients after orchidectomy, 158 men who had undergone surgery in Tuebingen between 2010 and 2014 were contacted by letter. The pseudonymization was done with a combination of letters and numbers, which were created with a key generator program. The patients received a questionnaire divided into several categories, these categories were questions on demography, pre- and postoperative pain as well as phantom pain, pain processing, quality of life, sex life and urological questions.


Recruitment information / eligibility

Status Completed
Enrollment 423
Est. completion date July 1, 2019
Est. primary completion date August 8, 2017
Accepts healthy volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Surgery at least 6 month before data collection - german speaking Exclusion Criteria: -

Study Design


Intervention

Behavioral:
pain after surgery


Locations

Country Name City State
Germany University Tuebingen, clinic of anästhesiology and intensiv care Tuebingen

Sponsors (1)

Lead Sponsor Collaborator
University Hospital Tuebingen

Country where clinical trial is conducted

Germany, 

Outcome

Type Measure Description Time frame Safety issue
Primary Incidence of Phantom Pain Number of patients with phantom pain of testis a minimum of 6 month post-surgery up to 5 years postsurgery
Secondary Functional Outcome Number of Participants with Incontinence, Difficult Urination, Stenosis of Urethra, Spraying of Urine and/or Corrective Surgery" a minimum of 6 month post-surgery up to 5 years postsurgery
Secondary Incidence of Chronic Postoperative Pain Number of patients with chronic pain after surgery and differences between the two groups a minimum of 6 month post-surgery up to 5 years postsurgery
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