Neuropathic Pain Clinical Trial
Official title:
Comparison of Pain-Related Changes in Cerebral Blood Volume in Burn Patients With Neuropathic Pain
The investigators will observe increased or decreased CBV in patients with thermal injury compared with the CBV in healthy controls.
Prevalence of chronic pain has been shown to be high after thermal injury. Post-burn
neuropathic pain causes chronic disabilities that is often difficult to treat effectively.
To study changes in the pain network associated with neuropathic pain, magnetic resonance
imaging(MRI) will be used to evaluate cerebral blood volume(CBV) in patients who was injuried
by burn. Over the fifty participants will be recruited. The participants will be comprised 30
subjects with neuropathic pain caused by thermal injury and 20 healthy contols. The 30
patients with neuropathic pain will be comprised divided into 15 electrical injury group and
15 non-electrical burn injury group. The patients are included the patients with severe
neuropathic pain that is rated at least 5 on the visual analogue scale (VAS), despite
treatments with gabapentin medication and other physical modalities. The intensity of
neuropathic pain will be measured using the visual analogue scale(VAS). Depressive mood will
be assessed using the Beck Depression Scale. CBV maps will be compared between burn patients
and controls. And the relationship between individual participant CBV(measured in voxels),
BDS and VAS score will be also examined.
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