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Pgp Transporter and CNS Biodistribution of Ondansetron in Healthy Volunteers

Neuropathic Pain Clinical Trial

Official title:
Effects of Pgp Transporter Inhibition on CNS Biodistribution of Ondansetron in Healthy Volunteers

Clinical Trial Summary

To determine the time-course of plasma and CSF concentrations of intravenous (IV) ondansetron in healthy subjects, with and without selective inhibition of Pgp efflux transporter.

Clinical Trial Description

The study hypothesis is that inhibition of Pgp efflux transporters will increase the CNS bio-distribution of the 5-HT3R antagonist ondansetron. Specifically: 1. Intravenous administration of ondansetron is expected to yield low CSF exposure. 2. Co-administration of ondansetron with intravenous tariquidar, an inhibitor of Pgp efflux transporters, will result in increased CSF exposure of ondansetron. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03809234
Study type Interventional
Source Washington University School of Medicine
Contact
Status Terminated
Phase Phase 1
Start date May 20, 2019
Completion date November 30, 2020
View Details
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