Neuropathic Pain Clinical Trial
Official title:
Structural and Functional Brain Reorganization in Neuropathic Pain: Basal State of Local Cerebral Blood Flow and Functional Connectivity
Neuropathic pain is a medical condition involving allodynia (painful perceptions in response
to stimuli that normally are not) and spontaneous pain (occurring at rest, without
stimulation).
This pain is secondary to nervous system injury affecting the sensory system. The lesion is
either at the nerve endings of the spinal cord or brain.
It induces a loss of sensitivity and likely reorganization of brain activity that are causing
pain and which are the subject of this study.
Previous studies in functional neuroimaging has focused on brain areas activated during
allodynic stimuli compared to non-painful stimuli. The abnormalities have been reported, but
it was not possible to conclude formally. The authors failed to assess the part of the effect
of the loss of sensory afferents (deafferentation) and the basal brain function.
Indeed, the operation without any sensory stimulation is not known yet is the initial level
of activity which is the benchmark for studying brain function during stimulation. The
objective of this study is to understand what are the cortical systems of allodynic
dysfunctional in patients compared with controls at baseline.
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