Neuropathic Pain Clinical Trial
Official title:
Status of the Hypothalamic-pituitary-gonado- Adrenal Axis (HHSG) in Patients With Neuropathic Pain
Chronic pain is often associated with a chronic stress and HHSG axis plays a pivotal role in maintaining homeostasis. The literature reports that pain in patients treated with opioids, significant changes are taking place in this axis with a collapse in hormone concentrations that are correlated with the decline on tests of quality of life and psychological testing. The investigators hypothesis is that this "endocrinopathy" could also be present in patients treated for neuropathic pain with other drug classes as opiates (antidepressants, antiepileptics), and may explain, at least in part, the impairement of the quality of life of these patients.
Day of inclusion: Blood sample for analysis of several hormones (cortisol, ACTH, SHBG, total
testostérone et S-DHEA, βœstradiol et progestérone for women, LH, FSH).
Day +1: salivary samples (at wake-up, 30 minutes after wake-up, at lunch, at 06:00 pm and
before sleep).
Day +2: salivary samples (at wake-up, 30 minutes after wake-up).
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Observational Model: Case Control, Time Perspective: Cross-Sectional
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