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Longitudinal Cortical Demyelination in Multiple Sclerosis and Related Disorders

Multiple Sclerosis Clinical Trial

Official title:
Longitudinal Investigation of Cortical Demyelination and Meningeal Inflammation in Multiple Sclerosis and Related Disorders

Clinical Trial Summary

In this protocol, a combination of MRI, blood, and cerebrospinal fluid (CSF) analysis will be used to understand the natural history, underlying immunologic mechanisms, and clinical implications of central nervous system (CNS) lesions, in particular lesions in the cerebral cortex, in multiple sclerosis (MS) and other inflammatory and autoimmune disorders affecting the CNS. Patients with these disorders, as well as healthy controls, will undergo baseline clinical evaluation and testing, bloodwork, and MRI, with follow up clinical evaluation, bloodwork, and MRI at years 1, 3, and 6. Additional MRIs may be performed in patients with possible new lesion formation or to compare MRI techniques. Lumbar puncture will be performed on participants who are not currently being treated with disease modifying therapies and who are willing to undergo the procedure.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05982925
Study type Observational
Source Icahn School of Medicine at Mount Sinai
Contact Erin S Beck, MD, PhD
Phone 212-241-2474
Email erin.beck@mssm.edu
Status Recruiting
Phase
Start date May 6, 2022
Completion date May 1, 2030
View Details
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