Healthy Clinical Trial
Official title:
Evaluation of Neuromuscular Diseases
The peripheral nervous system is the portion of the nervous system outside of the brain and
spinal cord. It includes the 12 pairs of cranial nerves, 31 pairs of spinal nerves and their
branches, nerves responsible for sensation and maintenance of normal body functions
(sympathetic and parasympathetic nerves).
Years of research using clinical examinations, microscopic examinations, and
electrophysiology have made the peripheral nervous system the best-studied and most
available portion of the nervous system. However, even with all of the extensive studies
conducted on the peripheral nervous system, many conditions remain unclassified.
The EMG Laboratory at the NIH concentrates on studying disorders of the peripheral nervous
system. This protocol was designed to allow the EMG Laboratory to;
I) Learn more about established diseases of the peripheral nervous system
II) Identify and characterize new diseases of the peripheral nervous system
III) Assess current techniques in the diagnosis of diseases of the peripheral nervous system
IV) Refine old methods and develop new ones for the diagnosis of diseases of the peripheral
nervous system.
Combined with careful clinical examination, electrophysiology and histopathology have
rendered the peripheral nervous system the best studied and most accessible level of the
nervous system. But even after intensive diagnostic evaluation of peripheral neuropathies in
large diagnostic centers, 24 to 70% of disorders remain unclassified. Analogous statistics
for disorders of muscle and neuromuscular transmission are not known but probably similar,
if not worse. Clearly, detailed diagnostic characterization of disorders of the peripheral
nervous system is the first stage in clinical intervention.
Currently, the EMG Laboratory at the NIH offers complete clinical, electrophysiologic, and,
when appropriate, pathologic evaluations on all referrals from the other Branches and
Institutes. Since these referrals come primarily from within the NIH, most disorders are
secondary to other systemic disease. This protocol is designed to extend the services to
direct referrals of primary disorders of the peripheral nervous system. The purposes are
first, to learn more about established diseases; second, to identify and characterize new
diseases; third, to assess current methodologies and technologies; and fourth, to refine old
methods and develop new ones. Under this umbrella protocol, individual cases and clinical
series can be investigated.
;
N/A
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT06052553 -
A Study of TopSpin360 Training Device
|
N/A | |
| Completed |
NCT05511077 -
Biomarkers of Oat Product Intake: The BiOAT Marker Study
|
N/A | |
| Recruiting |
NCT04632485 -
Early Detection of Vascular Dysfunction Using Biomarkers From Lagrangian Carotid Strain Imaging
|
||
| Completed |
NCT05931237 -
Cranberry Flavan-3-ols Consumption and Gut Microbiota in Healthy Adults
|
N/A | |
| Completed |
NCT04527718 -
Study of the Safety, Tolerability and Pharmacokinetics of 611 in Adult Healthy Volunteers
|
Phase 1 | |
| Terminated |
NCT04556032 -
Effects of Ergothioneine on Cognition, Mood, and Sleep in Healthy Adult Men and Women
|
N/A | |
| Completed |
NCT04107441 -
AX-8 Drug Safety, Tolerability and Plasma Levels in Healthy Subjects
|
Phase 1 | |
| Completed |
NCT04065295 -
A Study to Test How Well Healthy Men Tolerate Different Doses of BI 1356225
|
Phase 1 | |
| Completed |
NCT04998695 -
Health Effects of Consuming Olive Pomace Oil
|
N/A | |
| Completed |
NCT01442831 -
Evaluate the Absorption, Metabolism, And Excretion Of Orally Administered [14C] TR 701 In Healthy Adult Male Subjects
|
Phase 1 | |
| Terminated |
NCT05934942 -
A Study in Healthy Women to Test Whether BI 1358894 Influences the Amount of a Contraceptive in the Blood
|
Phase 1 | |
| Recruiting |
NCT05525845 -
Studying the Hedonic and Homeostatic Regulation of Food Intake Using Functional MRI
|
N/A | |
| Completed |
NCT05515328 -
A Study in Healthy Men to Test How BI 685509 is Processed in the Body
|
Phase 1 | |
| Completed |
NCT04967157 -
Cognitive Effects of Citicoline on Attention in Healthy Men and Women
|
N/A | |
| Completed |
NCT05030857 -
Drug-drug Interaction and Food-effect Study With GLPG4716 and Midazolam in Healthy Subjects
|
Phase 1 | |
| Recruiting |
NCT04494269 -
A Study to Evaluate Pharmacokinetics and Safety of Tegoprazan in Subjects With Hepatic Impairment and Healthy Controls
|
Phase 1 | |
| Recruiting |
NCT04714294 -
Evaluate the Safety, Tolerability and Pharmacokinetics Characteristics of HPP737 in Healthy Volunteers
|
Phase 1 | |
| Completed |
NCT04539756 -
Writing Activities and Emotions
|
N/A | |
| Recruiting |
NCT04098510 -
Concentration of MitoQ in Human Skeletal Muscle
|
N/A | |
| Completed |
NCT03308110 -
Bioavailability and Food Effect Study of Two Formulations of PF-06650833
|
Phase 1 |