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Neurologic Complication clinical trials

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NCT ID: NCT06068673 Completed - Neurosurgery Clinical Trials

The Potential Impact of Clindamycin on Neurosurgery Patients.

Start date: March 1, 2023
Phase: N/A
Study type: Interventional

A prospective, open-label, single center, controlled trial. 44 patients that underwent neurosurgery or presented meningitis signs, for whom Clindamycin add-on therapy to assess its effect on neurological complication in relation to Neuron-specific enolase (NSE) and Neurotensin biomarkers levels.

NCT ID: NCT04418609 Completed - Clinical trials for Neurologic Complication

Neuro-COVID-19: Neurological Complications of COVID-19

Neuro-COVID
Start date: May 1, 2020
Phase:
Study type: Observational

The prevalence and typical patterns of neurological complications in hospitalized COVID-19 patients admitted to the intensive care units of the University Hospital Zurich will be investigated. The impact of neurological complications among COVID-19 patients on mortality, functional outcome, and organizational outcomes will be analyzed.

NCT ID: NCT04387513 Completed - Endocarditis Clinical Trials

Impact of Early Cardiac Surgery in Severe Left Endocarditis With Neurological Complications: a Retrospective Study

ICE-COCA
Start date: August 1, 2010
Phase:
Study type: Observational

Surgical delay in severe endocardits, with neurological complications, is still debated. Early surgery, if indicated, permits to avoid new embolic events, or to fix valvular damages, but can create or increase a cerebral hemorrage. Hypothesis Cardiac surgery, as soon as possible, if indicated, would reduce mortality, in severe left endocarditis, with neurological complications. Primary objective To assess the impact of early versus late cardiac surgery on mortality at 1 year, in patients with severe endocarditis, with neurological complications. Primary endpoint: 1) Mortality at 1 year Secondary endpoints: 1. Analyze the factors associated with neurological degradation 2. Evaluate the neurological tolerance of cardiac surgery.

NCT ID: NCT04188717 Completed - Clinical trials for Postoperative Complications

Incidence, Risk Factors, Predictors and Survival for Neurological Complications After Liver Transplantation

Start date: January 1, 2010
Phase:
Study type: Observational

Liver transplantation is the definitive treatment in patients with chronic liver disease. Neurological complications (NC) occur commonly after liver transplantation. The investigators aim to evaluate the incidence, risk factors and predictors of neurological complications in both living donor and deceased donor transplantation done in the hospital. Between January 2011 to December 2016, 253 liver transplant recipients were recruited for this study. The investigators recorded the incidence of neurological complications, their median time of onset, their relationship with etiology of chronic liver disease, and the risk factors for the complications. The investigators also studied the relationship of neurological complications with duration of hospital and ICU stay, and survival. Using multivariate forward regression analysis , the investigators developed a scoring system for prediction of neurological complications in liver transplantation.

NCT ID: NCT04158024 Not yet recruiting - Clinical trials for Congenital Heart Disease in Children

Erector Spinae Plane Block in Congenital Heart Disease Patients

Start date: January 2024
Phase: N/A
Study type: Interventional

Pediatric cardiac patients undergoing surgical anesthesia are at an increased risk of poor neurologic outcome (20-50%). Unattenuated anesthetic exposure and pain contributes to physiologic perturbations that may increase neurologic morbidity. Because of the often-large exposure to anesthetic agents in these cardiac children, at such a young age and the potential modifying anesthetic practice that could lead to improved neurodevelopmental outcomes and surgical recovery is paramount. Regional anesthesia such as thoracic epidurals provide effective analgesia and reduced intraoperative anesthetic needed but carry devastating sequelae neurological risks of epidural hematomas after anticoagulation during cardiopulmonary bypass (CPB). Recently, a newly described erector spinae plane block (ESPB) is superficial to neuraxial or vascular structures, providing opportunity to be placed with less risk for surgery requiring CPB. This block has been described as effective regional anesthesia for adult cardiac surgery.

NCT ID: NCT04070131 Active, not recruiting - Cancer Clinical Trials

Horse Assisted Rehabilitation Postoncologic Treatment in Children and Adolescents: Physical and Psychological Effects

Start date: October 15, 2019
Phase: N/A
Study type: Interventional

Clinical trial on the physical and psychological effects of Horse Assisted Rehabilitation after the treatment of cancer in children 4 to 18 years of age.

NCT ID: NCT03866876 Recruiting - Clinical trials for Neurologic Complication

Eucapnic pH Compared With Arterial pH and Base Deficit

PHE
Start date: September 1, 2018
Phase:
Study type: Observational

Neonatal asphyxia per partum can be complicated by severe neurologic sequelae and can lead to neonatal death. Of the 0.2% of live births to cerebral palsy, 10 to 28% would be secondary to neonatal acidosis. Only metabolic acidosis plays a neurotoxic role, explaining the recent interest of Racinet et al. in the development of a new biochemical marker, more specific than pH or base deficit, of neonatal asphyxia per partum at risk of anoxo-ischemic encephalopathy. This eucapnic neonatal pH raises the hope of a biochemical marker of situations at risk of poor prognosis, with high diagnostic value, prognostic and forensic. Our hypothesis is that eucapnic pH is more efficient than cord blood arterial pH and base deficit in the prediction of adverse neurologic outcomes.