The Potential Impact of Clindamycin on Neurosurgery Patients.

Status Completed

Clinical Trial Summary

A prospective, open-label, single center, controlled trial. 44 patients that underwent neurosurgery or presented meningitis signs, for whom Clindamycin add-on therapy to assess its effect on neurological complication in relation to Neuron-specific enolase (NSE) and Neurotensin biomarkers levels.

Clinical Trial Description

1. This is a prospective, open-label, single center, controlled trial. 44 patients that underwent neurosurgery or presented meningitis signs, for whom Clindamycin add-on therapy is prescribed (900 - 1200 mg twice daily) will be recruited from Alexandria University Main Hospital. 2. Whole blood samples will be collected for Analyses of Neuron-specific enolase (NSE) and Neurotensin will be detected by ELISA. 3. All patients will be assessed for complete blood count (CBC), kidney function, liver function, Methodology - Patients will be enrolled if they underwent surgery or presented with clinical signs of meningitis. - All enrolled 44 patients will be divided into two groups; Group I are patients who will receive clindamycin added-on therapy. Group II patients will be managed with the standard regimen. - Complete physical, laboratory, and radiological assessment will be done for all patients - All patients will be followed up during 2 weeks period. - Serum samples will be collected for measuring the biomarkers. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06068673
Study type	Interventional
Source	Damanhour University
Contact
Status	Completed
Phase	N/A
Start date	March 1, 2023
Completion date	December 30, 2023

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