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Neurogenic Inflammation clinical trials

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NCT ID: NCT05411900 Recruiting - Pain Clinical Trials

BotulInum Toxin Type A for Peripheral Neuropathic Pain in subjEcts With Carpal Tunnel Syndrome

INjECT
Start date: May 25, 2022
Phase: Phase 2
Study type: Interventional

The main purpose of the study is to assess the safety and efficacy of repeated administrations of BoNT-A in subjects with NP attributable to carpal tunnel syndrome (CTS) through a randomized, double-blind, placebo-controlled study. Further research has shown that BoNT-A has analgesic properties independently from its action on muscle tone, possibly by acting on neurogenic inflammation. Therefore, the study drug may be better than other treatments surgical or non-surgical currently available for the treatment of CTS.

NCT ID: NCT03804034 Completed - Clinical trials for Orthodontic Appliance Complication

Importance of Neurogenic Inflammation in the Angiogenic Response of the Dental Pulp as a Defensive Response

Start date: July 2, 2013
Phase: N/A
Study type: Interventional

This study measures SP, CGRP and VEGF expression in human dental pulp under occlusal trauma induced by occlusal interferences under moderate orthodontic forces or under a combination of occlusal trauma and moderate orthodontic forces because in clinical reality, patients under orthodontic treatment experience a combination of these stimuli on their pulp tissue.

NCT ID: NCT03663140 Completed - Clinical trials for Periodontal Diseases

Neurogenic Inflammation in Peri-implant and Periodontal Diseases

Start date: January 1, 2011
Phase:
Study type: Observational [Patient Registry]

Regulatory effects of some neuropeptides substance-P (SP), neurokinin-A (NKA), calcitonin gene-linked peptide (CGRP) and neuropeptide-Y (NPY) )on inflammatory responses in periodontal disease has been described; however, the impact of neuropeptide levels are not clearly defined in healthy and diseased peri-implant tissues.ın order to evaluate the situation, thirty-nine implants that have been loaded over the past 12 months and their symmetrically matching teeth were evaluated using a split-mouth study design. Clinical periodontal examinations included the Silness-Löe plaque index, Löe-Silness gingival index, bleeding on probing, probing pocket depth and clinical attachment level parameters were determined. Gingival crevicular fluid (GCF)/Periimplant sulcular fluid (PISF) samples were collected, and the levels of the neuropeptides were determined by enzyme-linked immunosorbent assay. Correlations between GCF/PISF neuropeptide levels and the clinical examination parameters were evaluated in the peri-implant/periodontal soft tissues.

NCT ID: NCT03346668 Completed - Clinical trials for Frontal Fibrosing Alopecia

Role of Neurogenic Inflammation and Topical 6% Gabapentin Therapy in Symptomatic Scarring Alopecia

Start date: January 28, 2016
Phase: Early Phase 1
Study type: Interventional

This study will serve as a pilot study to determine the efficacy and safety of topical gabapentin in the treatment of symptomatic scarring alopecia.

NCT ID: NCT02653703 Completed - Inflammation Clinical Trials

L-menthol as a Topical Counter-irritant to TRPA1-induced Neurogenic Inflammation and Pain

Start date: October 2014
Phase: N/A
Study type: Interventional

The aim of this study is to quantitatively characterize the effects of L-menthol as a topical counter-irritant on cutaneous pain and hyperalgesia provoked by topical application of the TRPA1-agonist trans-cinnamaldehyde (CA) in healthy human volunteers.

NCT ID: NCT01933074 Completed - Overactive Bladder Clinical Trials

Clinical and Biochemical Evidence of Neurogenic Inflammation in Women With Urinary Urgency

Start date: January 2013
Phase: N/A
Study type: Observational

The purpose of this study is to gain a better understanding of what causes urinary urgency in women by asking about different symptoms and measuring biomarker levels in their urine. Understanding the underlying causes of urinary urgency will allow us to develop treatment options to better take care of women with urinary urgency.

NCT ID: NCT01881646 Completed - Surgery Clinical Trials

Postoperative Neuroinflammation and Cognitive Dysfunction After Abdominal Surgery

POPE
Start date: June 2013
Phase: Phase 4
Study type: Interventional

The main purpose of this study is to assess the induction of neuroinflammation in brain regions of interest for learning and memory in adult patients undergoing urological surgery under general anesthesia

NCT ID: NCT01370837 Completed - Diabetes Mellitus Clinical Trials

Neurogenic Inflammation in Diabetes

Start date: May 2012
Phase: N/A
Study type: Interventional

Polyneuropathy is a complication of diabetes mellitus which leads to decreased sensation in arms and legs. This in turn can lead to the development of (infected) foot ulcers. Charcot's disease can also be a consequence of polyneuropathy. Patients with Charcot's disease suddenly develop a red, warm and swollen foot, like an infection. Charcot's disease leads to foot fractures. After these fractures have healed, the shape of the foot can be dramatically altered. This altered shape of the foot increases the risk of developing foot ulcers. Nerves are important in regulating the inflammatory response. This study aims to investigate whether the inflammatory response is different in patients with polyneuropathy with and without a history of Charcot's disease.