Lung Cancer Clinical Trial
Official title:
Neurocognitive Functioning in Adults With Upper Aerodigestive System Cancers
RATIONALE: Gathering information about how often problems with neurocognitive functioning
occur in patients with newly diagnosed upper aerodigestive tract cancers may help doctors
learn more about the disease.
PURPOSE: This clinical trial is studying neurocognitive functioning in patients with newly
diagnosed upper aerodigestive tract cancers receiving treatment at Henry-Joyce Cancer
Clinic.
OBJECTIVES:
Primary
- To establish an estimate of the prevalence of baseline neurocognitive impairment prior
to initiation of outpatient cancer treatment.
- To establish an estimate of the incidence of neurocognitive impairment during
outpatient cancer treatment.
- To describe how neurocognitive functioning changes over time during cancer treatment.
Secondary
- To identify sociodemographic and clinical factors associated with neurocognitive
impairment.
- To examine health-related outcomes associated with neurocognitive impairment.
OUTLINE: Patients undergo interview to complete measures of domain-specific neurocognitive
functioning, global neurocognitive functioning, subjective neurocognitive functioning,
delirium, physical functioning, symptom prevalence and distress, mood states, and
medications at baseline before initiation of cancer treatment, at scheduled treatment
visits, and at the follow-up visit 3 months after completion of cancer treatment.
Measures of comorbidity, alcohol use, sensory functioning (vision and hearing), and
sociodemographic are completed at baseline only. Cancer-related information (diagnosis,
staging, and sites of metastasis, if applicable), treatment-related information (planned
treatment regimen - chemotherapy and/or radiation therapy), and current medications are
obtained at baseline by medical record review.
Health service use and complications are assessed at each scheduled treatment visit and at
the 3-month post-treatment follow-up visit. Measures of domain-specific neurocognitive
functioning, coping, and quality of life are completed at baseline and at the 3-month
follow-up visit.
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