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A Phase I Study of ABT-888 in Combination With Conventional Whole Brain Radiation Therapy (WBRT) in Cancer Patients With Brain Metastases

Neoplasm Metastasis Clinical Trial

Official title:
A Phase 1 Study Evaluating the Safety, Tolerability and Pharmacokinetics of ABT-888 in Combination With Whole Brain Radiation Therapy in Subjects With Brain Metastases

Clinical Trial Summary

This Phase I clinical trial is studying the side effects and best dose of ABT-888 when given together with Whole Brain Radiation Therapy (WBRT) in treating patients with brain metastases.

Clinical Trial Description

This is a Phase 1, multicenter, dose-escalation study evaluating the safety, tolerability and pharmacokinetics of the PARP inhibitor ABT-888 in combination with conventional whole brain radiation therapy (WBRT) in the treatment of subjects with solid tumors metastatic to the brain. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00649207
Study type Interventional
Source AbbVie
Contact
Status Completed
Phase Phase 1
Start date March 2008
Completion date March 2013
View Details
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