Massage Percussion for Passage of Urolithiasis Fragments After

Status Recruiting

Clinical Trial Summary

Flexible ureteroscopy is characterized as first-line therapy for renal stones < 2 cm in size. Stones are commonly treated with dusting or fragmentation techniques which requires passage of stone fragments after surgery. Quoted stone free rate after flexible ureteroscopy is approximately 40-60% with a dusting technique. Residual fragments are often under 1mm in size and can layer in the lower pole of the kidney, complicating spontaneous stone passage. Improving the stone free rate after surgery decreases the need for secondary surgeries and decreases risk of future stone events. Numerous techniques have been proposed to increase stone passage including positional changes and percussion therapy. To date, there is overall limited data a lack of techniques that can be readily available in the outpatient setting, easily added to scheduled appointments, reproducible results and well tolerated by patients.

Clinical Trial Description

Researchers in China have developed a proprietary oscillation machine to be used in an outpatient setting. The External Physical Vibration Lithecbole (EPVL) is used to provide vibration after stone fragmentation to facilitate movement of fragments into a more favorable orientation for stone passage. After extracorporeal shockwave lithotripsy and ureteroscopy, use of EPVL after surgery has been shown to increase stone free rate. Chest percussion for cystic fibrosis patients has been adapted for use after ureteroscopy. After undergoing extracorporeal shockwave lithotripsy, patients are placed in a percussion physiotherapy vest, given diuretics and positioned in Trendelenburg. Imaging obtained before and after percussion demonstrates successful stone movement and increases stone free rates in several different protocols compared to patients who do not receive percussive therapy. Percussion therapy is clearly effective to improve stone free rates after ureteroscopy and is effective regardless of technique, protocol, or percussive device. However, proposed techniques with EPVL and chest physiotherapy vests can be expensive, cumbersome and require specialty equipment. In addition, proposed equipment in prior studies is not readily available in outpatient clinics. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05872230
Study type	Interventional
Source	Vanderbilt University Medical Center
Contact	Ryan Hsi
Phone	615-343-2036
Email	ryan.hsi@vumc.org
Status	Recruiting
Phase	N/A
Start date	February 1, 2024
Completion date	December 2025

View Details

See also
Status	Clinical Trial	Phase
Enrolling by invitation	`NCT04746378` - PRedictive Accuracy of Initial Stone Burden Evaluation.
Recruiting	`NCT05100017` - Methocarbamol vs Oxybutynin for Management of Pain and Discomfort S/P Ureteroscopy Procedure	N/A
Recruiting	`NCT03692715` - Antibiotic Prophylaxis Before Shock Wave Lithotripsy	Phase 4
Completed	`NCT02547805` - Evaluate the Effect of ALLN-177 in Reducing Urinary Oxalate in Patients With Secondary Hyperoxaluria and Kidney Stones Over 28 Days	Phase 2
Completed	`NCT02289755` - Evaluating ALLN-177 for Reducing Urinary Oxalate Excretion in Calcium Oxalate Kidney Stone Formers With Hyperoxaluria	Phase 2
Completed	`NCT01650935` - Comparison of DASH With Oxalate Restricted Diet on Urine in Recurrent Stone Formers With Hyperoxaluria	N/A
Completed	`NCT01690039` - Influence of Polymorphisms in the ATP6V1 Gene of the V-ATPase on the Development of Incomplete Distal Renal Tubular Acidosis
Completed	`NCT01295879` - Vitamin D Repletion in Stone Formers With Hypercalciuria	Phase 4
Recruiting	`NCT05014178` - Kidney Sodium Functional Imaging
Not yet recruiting	`NCT06199102` - The High Initial Dose of Monitored Vitamin D Supplementation in Preterm Infants.	N/A
Recruiting	`NCT04374188` - Efficacy of Ciprofloxacin Therapy in Avoidance of Sepsis in Patient Undergoing Percutanous Nephrolithotomy	N/A
Recruiting	`NCT04367155` - Efficacy of Tranexamic Acid on Blood Loss During Percutaneous Nephrolithotomy.	N/A
Recruiting	`NCT05701098` - SOUND Pivotal Trial - (Sonomotion stOne comminUtion resoNance ultrasounD)	N/A
Recruiting	`NCT04389853` - Mini-PNCL vs fURS in Management of Nephrolithiasis	N/A
Completed	`NCT03348228` - Effect of Hydroxycitrate on Urine Chemistry	N/A
Completed	`NCT05350423` - Trial Assessing Renal Damage During Ureteroscopy	N/A
Completed	`NCT03454139` - Subcostal TAP Block For Percutaneous Nephrolithotomy	N/A
Recruiting	`NCT02279927` - Prospective Comparison Between Different Laser Settings for Ureteral \ Kidney Stones Treatment During Ureteroscopy	N/A
Completed	`NCT02276924` - Diagnostic Relevance of Laser Confocal Microscopy for the Screening of Upper Urinary Tract Tumors	N/A
Completed	`NCT00159393` - Percutaneous Nephrolithotomy: A Registry and Database

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Massage Percussion for Passage of Urolithiasis Fragments After Ureteroscopy.

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms