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Nephrolithiasis clinical trials

View clinical trials related to Nephrolithiasis.

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NCT ID: NCT00587041 Completed - Crohn's Disease Clinical Trials

Use of Oral Probiotics to Reduce Urinary Oxalate Excretion

Start date: February 2006
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study was to determine the effect of two probiotic preparations (Agri-King Synbiotic and Oxadrop) on urinary oxalate excretion in patients with mild hyperoxaluria. Probiotics are live microorganisms thought to be beneficial to the host organism. Hyperoxaluria is a hereditary disorder that causes a special kind of stone to form in the kidney and urine. Oxalates are naturally-occurring substances found in plants, animals, and in humans. Excretion of oxalates in the urine is a risk factor for kidney stone formation. Our hypothesis was that the mild hyperoxaluria is due to over absorption of oxalate from food and that probiotics will improve gastrointestinal barrier function to decrease oxalate absorption across the gut (and hence its elimination in the urine). In the study, participants were randomized to placebo, Agri-King Synbiotic, or Oxadrop, and were treated for 6 weeks. Patients were maintained on a controlled diet to remove the confounding variable of differing oxalate intake and availability from food.

NCT ID: NCT00504283 Completed - Kidney Stone Clinical Trials

An Analgesia Protocol for Acute Renal Colic in the Emergency Department

Start date: February 2007
Phase: N/A
Study type: Interventional

An analgesia protocol for acute renal colic will lead to faster significant reductions in pain than prior practice.

NCT ID: NCT00448123 Completed - Kidney Stones Clinical Trials

The Efficacy of Tamsulosin in the Treatment of Ureteral Stones in Emergency Department Patients

Start date: February 2007
Phase: N/A
Study type: Interventional

To determine if emergency department patients with acute ureteral colic pain due to a ureteral stone who are treated with tamsulosin, versus placebo, will experience a shorter time to passage of their stone or resolution of their pain. A secondary study objective will be to determine if there is a relationship between response to tamsulosin and stone size or position in the ureter.

NCT ID: NCT00428428 Completed - Kidney Stone Clinical Trials

Pharmacological Modulation of the Intrarenal Pressure During Endourological Procedures in the Upper Urinary Tract

Start date: February 2007
Phase: Phase 2/Phase 3
Study type: Interventional

The purpose of the study is to examine the effect of endoluminally administrated isoproterenol on pelvic pressure increase during flexible ureterorenoscopy in 14 humans. We propose that isoproterenol has potential of reducing intrarenal pressure during ureterorenoscopies. Lower intrarenal pressures may have the advantage of facilitating the procedure and reducing intraoperative complications as bleeding and infections.

NCT ID: NCT00416052 Completed - Clinical trials for Calcium Nephrolithiasis

Relation Between Bone Density and the Regulation of Mineral Metabolism in Renal Stone Formers

Start date: March 2004
Phase: N/A
Study type: Observational

Accumulating evidence indicated that renal calcium stone formers often exhibit a low bone density. Therefore we want to test the hypothesis, that the mineral (calcium) metabolism is differently regulated in calcium stone formers with low as opposed to high bone density.

NCT ID: NCT00381849 Completed - Cystinuria Clinical Trials

Use of an Herbal Preparation to Prevent and Dissolve Kidney Stones

Start date: April 2006
Phase: Phase 1/Phase 2
Study type: Interventional

We will investigate the safety and effectiveness of a mixture of 9 east Indian herbs known as Cystone regarding their ability to dissolve existing kidney stones and prevent formation of new ones. Cystine and calcium stone formers will be recruited for a 59 week trial. The first phase of the study will be two 6 weeks periods during which each subject will receive Cystone or placebo in random order (with a one-week wash out between 6 week treatment periods). The remaining 46 weeks, each subject will receive Cystone. End points are changes in urinary chemistries and stone burden by Computerized Tomography (CT) scanning.

NCT ID: NCT00360477 Completed - Kidney Calculi Clinical Trials

FloSeal Tubeless Exit Versus Cope Loop Nephrostomy Versus Fascial Stitch Following Percutaneous Nephrolithotripsy

Start date: June 2004
Phase: N/A
Study type: Interventional

The patient will be asked to participate in a research project designed to determine the best way to prevent bleeding and promote patient comfort after having kidney stones removed. Two standard methods for ending the surgery are being compared to a newer method. In one standard method, the patient will have a tube draining urine from the kidney after the procedure. This tube may also prevent bleeding from the kidney. In another standard method the patient will have a tube left internally that drains urine from the kidney to the bladder and a stitch will be used to close the incision and deeper tissues in the back. In the third potential option, a tube would be left internally to drain urine from the kidney to the patient's bladder and the surgical site would be filled with a clot promoting agent (FloSeal) which is a FDA approved agent specifically formulated to stop bleeding during surgical procedures.

NCT ID: NCT00351351 Completed - Kidney Stones Clinical Trials

Trial Comparing Dual Probe Ultrasonic Lithotripsy to a Single Probe Ultrasonic Lithotripsy

Start date: July 2006
Phase: N/A
Study type: Interventional

Percutaneous nephrolithotomy (PNL), in conjunction with intracorporeal lithotripsy, allows for the rapid removal of any kidney stone regardless of size. Currently, the choice of intracorporeal lithotripters includes ultrasonic, pneumatic, and combined ultrasonic/pneumatic energy sources. Recently, a novel dual probe design as been introduced by Cybersonics of Erie, Pennsylvania. This dual probe intracorporeal lithotrite is called the Cyberwand, and is composed of a fixed inner probe vibrating at an ultrasonic frequency with an outer probe vibrating at about 1,000 Hz. As this new design has the potential to revolutionize intracorporeal lithotripsy, we intend to compare this novel technology to currently available lithotripsy technology in a randomized clinical trial.

NCT ID: NCT00310908 Completed - Renal Calculus Clinical Trials

Comparison Between Tramadol Hcl and Other Analgesics in the Treatment of Renal Colic

Start date: September 2006
Phase: Phase 4
Study type: Interventional

The purpose of this study is to determine whether Tramadol Hcl is as effective as Voltaren a non-steroidal antiinflammatory drug, and Dipyrone in amelioration of the pain caused by acute renal colic.

NCT ID: NCT00289120 Completed - Kidney Stone Clinical Trials

Effect of Cola on Urinary Stone Risk Factors

Start date: November 2003
Phase: N/A
Study type: Interventional

Examine the effects of cola on risks of kidney stones