Neovascular Age-related Macular Degeneration Clinical Trial
Official title:
Retinal Pigment Epithelial Characteristics in Eyes With Neovascular Age-related Macular Degeneration Following Long-term Treatment With Anti Neovascular Endothelial Growth Factor
Purpose:
To assess retinal pigment epithelial (RPE) and retinal structural changes in eyes with
neovascular age-related macular degeneration (AMD) treated with anti-vascular endothelial
growth factor (anti-VEGF) during long-term follow-up and to evaluate morphological markers
potentially influencing prognosis.
Methods:
18 patients (18 eyes) with neovascular AMD were recruited subsequent to completion the
Avastin Versus Lucentis in Age Related Macular Degeneration (MANTA) study following a mean
period of 84 months (range: 69-93 months). After receiving a loading dose of 3 intravitreal
anti-VEGF injections subsequent to baseline of the MANTA study, patients were treated
as-needed [pro re nata (PRN)]. Functional and morphological changes were assessed using
spectral domain optical coherence tomography (SD-OCT).
n/a
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