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Clinical Trial Summary

A study to evaluate safety, tolerability, and pharmacokinetics of a single intravitreal injection of UBX1325 in patients diagnosed with diabetic macular edema (DME) or neovascular Age-Related Macular Degeneration.


Clinical Trial Description

This is a Phase 1, open-label, first-in-human (FIH), single-ascending dose (SAD) study consisting of approximately 4 cohorts. The total number of patients will be at least 3 per cohort plus 3 additional patients in the maximum tolerated dose (MTD) cohort in order to address the primary objective. Up to an additional 6 nAMD patients will be enrolled in the highest dose cohort. A single dose of UBX1325 will be administered intravitreally and all patients will be followed for approximately 6 months. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04537884
Study type Interventional
Source Unity Biotechnology, Inc.
Contact
Status Completed
Phase Phase 1
Start date October 8, 2020
Completion date January 25, 2022

See also
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