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Neointima clinical trials

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NCT ID: NCT05544864 Recruiting - Clinical trials for Coronary Artery Disease

Intracoronary Stenting and Restenosis - Randomized Trial of Drug-eluting Stent Implantation or Drug-coated Balloon Angioplasty According to Neointima Morphology in Drug-eluting Stent Restenosis 5

ISAR-DESIRE5
Start date: September 28, 2022
Phase: N/A
Study type: Interventional

The hypothesis of the study is, that there is a significant interaction in treatment effect between the OCT pattern of neointima (heterogeneous or homogeneous) and the type of percutaneous coronary intervention (drug-eluting stent or drug-coated balloon) in patients with in-stent restenosis.

NCT ID: NCT05451368 Recruiting - Clinical trials for Coronary Artery Calcification

Neointimal Features in Patients With Restenosis of Calcified Lesions

Start date: March 17, 2022
Phase:
Study type: Observational

Previous studies have suggested that restenosis (RS) after stenting is mainly due to smooth muscle cell proliferation and migration, but recent evidence suggests that in-stent restenosis(ISR) is associated with a number of factors. Coronary artery calcification is an independent predictor of ischaemia-mediated revascularisation 1 year after percutaneous coronary intervention (PCI) following RS.The characteristics of new neointima in patients with in-stent restenosis of calcified lesions are important issues to explore

NCT ID: NCT02545231 Completed - Atherosclerosis Clinical Trials

Effect of Low-dose vs. High-dose Pitavastatin on In-stent Restenosis

ELEVATE
Start date: February 2013
Phase: Phase 4
Study type: Interventional

To compare low dose (1mg) pitavastatin and high dose (4mg) pitavastatin on neointimal hyperplasia and atherosclerosis progression by using optical coherence tomography (OCT) and near-infrared spectroscopy (NIRS) at 12 months follow-up and on clinical adverse cardiovascular events during 3-year follow-up.

NCT ID: NCT02495662 Terminated - Renal Dialysis Clinical Trials

The LIPMAT Study: Liposomal Prednisolone to Improve Hemodialysis Fistula Maturation

LIPMAT
Start date: November 2015
Phase: Phase 2
Study type: Interventional

This study will investigate if liposomal prednisolone is effective in promoting arteriovenous fistula (AVF) maturation when administered to human subjects after surgical creation of a radio-cephalic AVF.

NCT ID: NCT02328521 Recruiting - Diabetes Mellitus Clinical Trials

Efficacy Study of Nicorandil on Neointima

Start date: December 2014
Phase: Phase 4
Study type: Interventional

The investigators aim to investigate the effect of oral nicorandil on neointima after coronary drug-eluting stent implantation in patients with diabetic mellitus.

NCT ID: NCT01752582 Completed - Clinical trials for Coronary Heart Disease

BuMA OCT Study(A Comparative Evaluation of the Extent of Neointima Formation at 3 Months After Implantation Using OCT)

Start date: December 2012
Phase: N/A
Study type: Interventional

The objective of this study is a comparative evaluation of BuMA stent and of EXCEL stent in terms of the extent of neointima formation at 3 months after implantation using OCT. This is a prospective, single center, randomized, open-label, non-inferiority study, which will enroll a total of 70 patients in Fuwai Hospital.All patients will be randomly assigned undergoing implantation of BuMA stent or EXCEL stent (in a 1:1 ratio). If non-inferiority was met, superiority test will be planned.