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Nausea, Postoperative clinical trials

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NCT ID: NCT05353426 Completed - Pain, Postoperative Clinical Trials

Paragastric Autonomic Blockade to Prevent Visceral Pain After Laparoscopic Sleeve Gastrectomy

PG-ANB
Start date: August 13, 2021
Phase: N/A
Study type: Interventional

Visceral pain (VP) following laparoscopic sleeve gastrectomy remains a substantial problem. VP is associated with autonomic symptoms, especially nausea and vomiting, and is unresponsive to traditional pain management algorithms aimed at alleviating somatic (incisional) pain. The present study was performed to evaluate the safety and effectiveness of laparoscopic paragastric autonomic neural blockade (PG-ANB) in managing the symptoms associated with VP following sleeve gastrectomy.

NCT ID: NCT05346588 Completed - Depression Clinical Trials

THRIVE Feasibility Trial

THRIVE
Start date: September 29, 2022
Phase: Phase 3
Study type: Interventional

To evaluate the feasibility of a pragmatic, large scale, comparative effectiveness, randomized evaluation of patient experience of intravenous propofol versus inhaled volatile anesthesia.

NCT ID: NCT04882501 Completed - Clinical trials for Nausea, Postoperative

Effects of Aromatherapy on Nausea Levels

Start date: April 19, 2021
Phase: N/A
Study type: Interventional

Aromatherapy is the therapeutic use of essential oils from plants for the improvement of physical, emotional, and spiritual well-being. Healthcare providers play an important role in improving the care of patients with nausea. Aromatherapy is a complementary therapy that may help with post-operative nausea in the adult post-operative bariatric patient population. The purpose of this study is to evaluate the effects of aromatherapy intervention on nausea levels with post-operative bariatric patients once they are on the surgical unit.

NCT ID: NCT04762381 Completed - Pain, Postoperative Clinical Trials

Dexamethasone and Robotic-assisted Hysterectomy

Start date: June 1, 2022
Phase: N/A
Study type: Interventional

Robotic-assisted hysterectomy is an alternative to laparoscopic surgery as part of a minimal invasive regimen. Several treatment strategies are followed to improve the overall outcome and minimize surgical stress. Glucocorticoids provide significant analgesic and antiemetic effects but its role in a fast-track, multi-modal setting is not settled when discharge is planned within 24-36 hours. This study will evaluate in a randomized trial the effect of a single dose of 24 mg dexamethasone on women undergoing robotic-assisted hysterectomy with regard to surgical stress measured by c-reactive protein as primary outcome and, further, other stress markers like white blood cells. The postoperative recovery will be registered in validated charts and questionnaires for pain and analgesic use, quality of recovery, incontinence, sexual and work life. Furthermore, in a sub-analysis, transcriptional profiling will be applied to explore, which parts of the innate and cellular immune system is activated to explore the mechanisms of surgical stress response. The hypothesis is that women undergoing robotic hysterectomy would benefit from peroperative glucocorticoid treatment on important life qualities like pain, fatigue, freedom of medications and resuming work and sexual activities. Further, future adjuvant peroperative regimens may be able to target the stress response in a more appropriate way

NCT ID: NCT04654429 Recruiting - Tremor Clinical Trials

Does Higher OT Temperature and IV Ondansetron Reduce Incidence of PSS in Parturients?

HOTON
Start date: October 13, 2020
Phase: Phase 4
Study type: Interventional

This study will look at the incidence of post-spinal shivering (PSS) among the obstetrics population and will investigate whether higher operation theater (OT) temperature range or/and IV Ondansetron are able to reduce the incidence of PSS. This is a double-blind, randomized, factorial study, patients will be grouped into 4 groups - LP, HP, LO, HO (L= low-temperature range, H= high-temperature range, P= placebo, O=Ondansetron). All patients undergoing cesarean section under spinal anesthesia will be recruited, and it will be conducted in obstetrics OT.

NCT ID: NCT04622618 Completed - Pain, Postoperative Clinical Trials

Optimal Dosing of Preoperative Gabapentin for Prevention of Postoperative Nausea and Vomiting

Start date: September 15, 2020
Phase: Early Phase 1
Study type: Interventional

Overall incidence of postoperative nausea and vomiting (PONV) after general anesthesia is 40-90 % . gabapentin has been incorporated into "fast-track" packages and improved recovery during surgery protocols to avoid unintended side effects associated with opioid alternatives. Interestingly, gabapentin has also been noted to reduce the effects of chemotherapy-induced nausea, effective in treatment of gravidarum hyperemesis, and postdural puncture emesis. Different dosing regimens were tested.The goal of the study is to determine the most effective dose of oral gabapentin given 1 hour prior to surgery on the occurrence and severity of PONV and drug side effects in the first 24 hours postoperatively to find the most effective dose of gabapentin with the least side effects.

NCT ID: NCT04618146 Recruiting - Pain, Postoperative Clinical Trials

Enhanced Recovery After Cesarean Section With Low Dose Intrathecal Morphine.

Start date: November 10, 2020
Phase: N/A
Study type: Interventional

This study is designed to see the effect of low dose intrathecal morphine on promting enhanced recovery after cesarean delivery with early ambulation and reduction of hospital stay.

NCT ID: NCT04610398 Completed - Pain, Postoperative Clinical Trials

Perioperative Dexamethasone Reduces Postoperative Pain and Nausea After Hip Arthroscopy

Start date: March 11, 2021
Phase: Phase 3
Study type: Interventional

The purpose of this study is to assess the effect of Dexamethasone on postoperative pain and nausea after hip arthroscopy.

NCT ID: NCT04589429 Recruiting - Pain, Postoperative Clinical Trials

Adding Nalbuphine for Control of Intrathecal Morphine Pruritus

Start date: October 15, 2020
Phase: Phase 2
Study type: Interventional

Intrathecal morphine causes intense itching which is very bothersome. Nalbuphine antagonizes this effect when given intravenously. This trial is to find out if nalbuphine added to intrathecal morphine has an effect on morphine related pruritus while still maintaining adequate analgesia.

NCT ID: NCT04533867 Completed - Pain, Postoperative Clinical Trials

Palonosetron vs. Ondansetron for Postoperative Nausea and Vomiting in Bariatric Surgery

Start date: August 15, 2020
Phase:
Study type: Observational [Patient Registry]

Evaluate the safety and efficacy of palonosetron versus ondansetron to reduce and control post-operative nausea in bariatric surgery.