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Myotonic Dystrophy Type 1 and Resistance Exercise — STYRK DM1  

Myotonic Dystrophy 1 Clinical Trial

Official title:
Recovery After Moderate-Heavy Resistance Exercise in Myotonic Dystrophy Type 1-patients

Clinical Trial Summary

The purpose of this study is to investigate the response after one bout of moderate-heavy resistance exercise in patients suffering from Myotonic Dystrophy type 1. There is still doubt about if these patients could benefit from resistance exercise, or if this mode of exercise is detrimental to their mobility and health. We aim to monitor the subjects during the recovery phase and investigate recovery in several ways.

Clinical Trial Description

Myotonic dystrophy type 1 (DM1) is an autosomal, dominantly inherited, muscular disease and the most common muscular dystrophy amongst adults. The disease is characterized by progressive myopathy and myotonia, first evident in the distal parts of the body: calves and forearms, further progressing towards proximal parts. A recent review by Voet and co-workers (2013) concludes that exercise is safe for DM1-patients, and based on our current knowledge, DM1-patients should be able to gain positive adaptations from exercise. However, the physiological outcomes of an exercise stimulus are not well studied in this population and because of alterations in important Ca2+ handling systems the recovery processes might be significantly different from healthy muscles. The aim of this study is to investigate the acute responses to moderate-heavy resistance exercise in DM1-patients. We aim to establish a timeline for recovery of muscle strength, measured as maximal voluntary contraction. In line with this, we want to investigate if any muscular damage has occurred with both direct and indirect measures, and possible mechanisms leading to muscle damage, i.e. impaired Ca2+ handling. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05036447
Study type Interventional
Source Norwegian School of Sport Sciences
Contact
Status Completed
Phase N/A
Start date June 14, 2021
Completion date April 30, 2023
View Details
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