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Clinical Trial Summary

The cognitive disorders of adult forms of myotonic dystrophies type 1 are heterogeneous (impairment of executive functions, visio construction and theory of the mind, which can progress to the stage of dementia). Nevertheless, patients have very different degrees of cognitive impairment. Expansion of CTG triplets disrupts the alternative splicing of mRNAs of various proteins, including the insulin receptor and Tau protein. Type 2 diabetes, associated with peripheral insulin resistance, is therefore common in this pathology. Type 2 diabetes,could to explain the cognitive impairment of patients, through the accelerated development of brain lesions (especially tauopathy and cerebral atrophy).


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04656210
Study type Observational
Source University Hospital, Lille
Contact Céline TARD, MD
Phone 0320445962
Email celine.tard@chru-lille.fr
Status Recruiting
Phase
Start date October 14, 2021
Completion date January 2029

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