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Myopia clinical trials

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NCT ID: NCT06029530 Withdrawn - Myopia Clinical Trials

Delaying the Onset of Nearsightedness Until Treatment Study

DONUT
Start date: January 1, 2024
Phase: Phase 1
Study type: Interventional

Participants eligible for the study will be randomized to one of three concentrations of atropine and followed for a month.

NCT ID: NCT05773118 Withdrawn - Myopia, Progressive Clinical Trials

A Unified Index to Predict the Success Probability of Myopia Control

Start date: January 2025
Phase: N/A
Study type: Interventional

Orthokeratology lenses (OK-lens) and multifocal contact lenses (MFCL) are optical devices designed to slow down the progression of myopia. Both treatments a long-term commitment from doctors and patients. This study aims to develop a unified index to predict the success probability of myopia control at the early stage of treatment.

NCT ID: NCT05481489 Withdrawn - Myopia Clinical Trials

Safety and Tolerability Evaluation of PRO-230 Ophthalmic Solution

PRO-230
Start date: February 1, 2023
Phase: Phase 1
Study type: Interventional

Phase I Study to evaluate safety and tolerability of PRO-230 (atropine sulphate 0.05%) ophthalmic solution through evaluation of incidence of non-expected adverse events (AE), photophobia, pupillary diameter, incidence of expected adverse events, and best near corrected visual acuity (BNCVA)

NCT ID: NCT05156190 Withdrawn - Myopia Clinical Trials

The Impact of Bright Classroom on Myopia

IMPACT
Start date: June 1, 2023
Phase: N/A
Study type: Interventional

This trial aims to test the effectiveness and practicality of study in the Bright Classrooms with skylight and artificial light renovation in reducing incident myopia in Chinese primary school children over three years, as compared to children studying in conventional classrooms.

NCT ID: NCT04352868 Withdrawn - Myopia Clinical Trials

Customizing Myopia Control With Multifocal Toric Contact Lens

Start date: September 1, 2020
Phase: N/A
Study type: Interventional

This study will evaluate the ability of toric multifocal contact lens to reduce the change of myopia progression in children (aged 8-12) with myopic astigmatism.

NCT ID: NCT04334369 Withdrawn - Myopia, Progressive Clinical Trials

Contact Lens and Myopia Control in Optometry School Students

Start date: December 12, 2018
Phase: N/A
Study type: Interventional

The purpose of the study is to determine the effect of Natural View Multifocal lenses, a soft multifocal lens, on retardation of myopia in an optometric student population. Close up work (i.e. reading, computer work, etc.) is thought to play a factor in the progression of myopia in young adults. The progression should be slowed if not stopped through the use of peripheral defocus lenses (Natural View Multifocal) to change the optics of the eye in order to focus the image on the peripheral retina as opposed to behind it.

NCT ID: NCT04140877 Withdrawn - Myopia Clinical Trials

Choroidal Changes Post Short Term Exposure To Virtual Reality Devices

MIRABILE
Start date: July 2020
Phase: N/A
Study type: Interventional

This is a prospective, randomized, controlled, contralateral eye, clinical study. The objective of the study is to determine the impact of Virtual Reality (VR) usage on choroidal thickness when viewed through a test display compared to a control (standard) VR display. The hypothesis is that there will be less choroidal thinning in the eye viewing the test VR screen compared to the eye viewing the control VR screen.

NCT ID: NCT03658239 Withdrawn - Myopia Clinical Trials

Corneal Biomechanics Study

Start date: December 2018
Phase: N/A
Study type: Interventional

The goal of the study is to investigate relationship between the corneal response to a temporary increase in intraocular pressure and corneal mechanical properties.

NCT ID: NCT03519490 Withdrawn - Myopia Clinical Trials

Can Distance Center and Near Center Multifocal Contact Lenses Control Myopia Progression in Children?

ADPADP
Start date: June 1, 2018
Phase: N/A
Study type: Interventional

Myopia has been increasing in prevalence and severity throughout the world over the last 30 years. Increasing levels of myopia are associated with increased frequency and severity of various ocular pathologies. Slowing myopia progression may help to reduce the future risks of these ocular pathologies. Conventional spectacles and contact lenses correct myopia by moving the central focus of the eye from in front of the retina to on the retina centrally. To varying degrees, these lenses allow the light to focus behind the retina, at varying peripheral retinal locations. These findings have led to efforts to design spectacle and contact lenses which correct peripheral hyperopic defocus, to reduce myopia progression. The consensus theory for how both multifocal contact lenses (MFCLs) and orthokeratology can control myopia progression is that they reduce, eliminate, or reverse relative peripheral hyperopic defocus. Existing published studies on the use of multifocal contact lenses to control myopia in humans have utilized lenses with the distance correction in the center with peripheral plus power to correct the peripheral blur. It is possible that one of the mechanisms responsible for myopia progression control with MFCLs is that when the eye is exposed to an image focused on the retina and simultaneously an image anterior to the retina, that this will suppress axial elongation and myopia progression. This mechanism would not be dependent on whether the anterior image is located in the central area of the retina or the peripheral area of the retina. While there are no published human studies demonstrating the effectiveness of near center MFCLs, this author has presented retrospective data showing no differences in myopia progression between near center and distance center MFCLs. Synergeyes, Inc.'s Duette contact lenses are hybrids of rigid gas permeable (RGP) with a silicon hydrogel peripheral portion or "skirt." They now make their MFCLs in both distance center (DC) and near center (NC) designs. This study will analyze the myopia progression of children after being randomly assigned to wear Duette MFCLs or Duette standard single vision contact lenses over a span of two years. Subjects assigned to the MFCL group will wear a DC lens on one eye and a NC lens on the other and will reverse this lens assignment every six months. Refractive changes will be measured by cycloplegic autorefraction and axial lengths will be measured with a laser interference biometer (Zeiss IOLMaster) at six-month intervals.

NCT ID: NCT02655432 Withdrawn - Cataract Clinical Trials

Performance of a Photoscreener for Vision Screening in a Haitian Pediatric Population

POPH
Start date: January 2016
Phase: Phase 0
Study type: Observational

Screening of haitian children between the ages of 3 and 6 years old for amblyogenic risk factors with the use of the Spot photoscreener. The photoscreener results will be compared to the complete ophthalmologic evaluation. Primarily, this will allow evaluation of the performance of the spot photoscreener in the haitian children population. Secondarily, this study will gather epidemiological information on vision problems in the haitian children population.